Polyketides and nitrogenous metabolites from the endophytic fungus Phomopsis sp. D15a2a

被引：4
作者：
Yu, Haiqian [1 ]
Hoefert, Simon-Patrick [2 ]
Moussa, Mariam [1 ]
Janiak, Christoph [2 ]
Mueller, Werner E. G. [3 ]
Umeokoli, Blessing O. [1 ,4 ]
Dai, Haofu [5 ]
Liu, Zhen [1 ]
Proksch, Peter [1 ]
机构：
[1] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany
[2] Heinrich Heine Univ Dusseldorf, Inst Inorgan & Struct Chem, Univ Str 1, D-40225 Dusseldorf, Germany
[3] Univ Med Johannes Gutenberg Univ Mainz, Inst Physiol Chem, D-55128 Mainz, Germany
[4] Nnamdi Azikiwe Univ, Dept Pharmaceut & Med Chem, Awka, Nigeria
[5] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 51期
关键词：
Phomopsis sp; Endophytic fungus; Polyketide; Peptide; CYCLIC TETRAPEPTIDE;
D O I：
10.1016/j.tetlet.2019.151325
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three new polyketides, phomopones A-C (1-3), one new cyclic tetrapeptide, 18-hydroxydihydrotentoxin (4), and a new amide, 6-hydroxyenamidin (5) together with a known derivative, enamindin (6) were obtained from the endophytic fungus Phomopsis sp. D15a2a isolated from the plant Alternanthera bettzickiana. The structures of the new compounds were elucidated by 1D, 2D NMR and HRMS data. The absolute configurations of the isolated metabolites were determined either by X-ray crystallography, Marfey's method or by converting the compounds to Mosher esters. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：4
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