Resolution of 2-octanol via lipase-catalyzed enantioselective acetylation in organic solvents

被引：0

作者：

Wang, Z

Li, ZQ

Yu, DH

Weng, L

Liu, M

Zhang, GR

Cao, SG ^{[1
]}

机构：

[1] Jilin Univ, Key Lab Mol Enzymol & Engn, Educ Minist, Changchun 130023, Peoples R China

[2] Jilin Univ, Life Sci & Technol Inst, Changchun 130023, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2004年 / 20卷 / 05期

关键词：

lipase; resolution; activity; enantioselectivity; 2-octanol;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The lipases from different sources were screened for their ability to catalyze the resolution of 2-octanol in organic solvents with vinyl acetate as the acylating reagent. The medium effect has been studied on the irreversible transesterification with varying water activity(a(w)). The influence of vinyl acetate concentration on it has also been investigated. Under the optimal conditions, the enantiomeric ratio(E value) of pseudomonas fluorescence lipase (PFL) exceeded 200 with an enantiomeric excess (e. e.) of S-2-octanol above 99% at a 51% degree of conversion.

引用

页码：575 / 578

页数：4

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