Anaemia characterises patients with myelofibrosis harbouring MplW515L/K mutation

被引：120

作者：

Guglielmelli, Paola

Pancrazzi, Alessandro

Bergamaschi, Gaetano

Rosti, Vittorio

Villani, Laura

Antonioli, Elisabetta

Bosi, Alberto

Barosi, Giovanni

Vannucchi, Alessandro M. ^{[1
]}

机构：

[1] Univ Florence, Dept Haematol, I-50134 Florence, Italy

[2] Policlin San Matteo, Lab Clin Epidemiol, Transplant Res Area, Unit Internal Med,Fdn Ist Ricovero & Cura Caratte, I-27100 Pavia, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 137卷 / 03期

关键词：

MPL mutation; myelofibrosis; JAK2(V617F); anaemia; myeloproliferative disorders;

D O I：

10.1111/j.1365-2141.2007.06565.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8.2%) had an MPL mutation, four of which (22%) co-existed with JAK2(V617F) mutation. When compared with MPL wild-type patients, irrespective of JAK2(V617F) status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0.02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0.002) and were more likely to require regular transfusional support (P = 0.012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.

引用

页码：244 / 247

页数：4

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