Default mode network can support the level of detail in experience during active task states

被引:179
作者
Sormaz, Mladen [1 ]
Murphy, Charlotte [1 ]
Wang, Hao-ting [1 ]
Hymers, Mark [1 ]
Karapanagiotidis, Theodoros [1 ]
Poerio, Giulia [2 ]
Margulies, Daniel S. [3 ]
Jefferies, Elizabeth [1 ]
Smallwood, Jonathan [1 ]
机构
[1] Univ York, Dept Psychol, York Y010 5DD, N Yorkshire, England
[2] Univ Sheffield, Dept Psychol, Western Bank, Sheffield S10 2TN, S Yorkshire, England
[3] CNRS, Inst Cerveau & Moelle Epiniere, Frontlab, UMR 7225, Paris, France
基金
欧洲研究理事会;
关键词
default model network; principal gradient; mind wandering; representational similarity analysis; POSTERIOR CINGULATE CORTEX; HUMAN BRAIN; SEMANTIC COGNITION; WANDERING MIND; FMRI; DEACTIVATION; CONNECTIVITY; ASSOCIATION; DISEASE; INPUT;
D O I
10.1073/pnas.1721259115
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Regions of transmodal cortex, in particular the default mode network (DMN), have historically been argued to serve functions unrelated to task performance, in part because of associations with naturally occurring periods of off-task thought. In contrast, contemporary views of the DMN suggest it plays an integrative role in cognition that emerges from its location at the top of a cortical hierarchy and its relative isolation from systems directly involved in perception and action. The combination of these topographical features may allow the DMN to support abstract representations derived from lower levels in the hierarchy and so reflect the broader cognitive landscape. To investigate these contrasting views of DMN function, we sampled experience as participants performed tasks varying in their working-memory load while inside an fMRI scanner. We used self-report data to establish dimensions of thought that describe levels of detail, the relationship to a task, the modality of thought, and its emotional qualities. We used representational similarity analysis to examine correspondences between patterns of neural activity and each dimension of thought. Our results were inconsistent with a task-negative view of DMN function. Distinctions between on- and off-task thought were associated with patterns of consistent neural activity in regions adjacent to unimodal cortex, including motor and premotor cortex. Detail in ongoing thought was associated with patterns of activity within the DMN during periods of working-memory maintenance. These results demonstrate a contribution of the DMN to ongoing cognition extending beyond task-unrelated processing that can include detailed experiences occurring under active task conditions.
引用
收藏
页码:9318 / 9323
页数:6
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