Phage Therapy in Veterinary Medicine

被引:46
作者
Loponte, Rosa [1 ]
Pagnini, Ugo [1 ]
Iovane, Giuseppe [1 ]
Pisanelli, Giuseppe [1 ]
机构
[1] Univ Naples Federico II, Dept Vet Med & Anim Prod, Via Federico Delpino 1, I-80137 Naples, Italy
来源
ANTIBIOTICS-BASEL | 2021年 / 10卷 / 04期
关键词
alternative to antibiotics; bacteriophages; phage therapy; veterinary medicine; pets; CAMPYLOBACTER-JEJUNI COLONIZATION; RESISTANT PSEUDOMONAS-AERUGINOSA; REDUCE SALMONELLA COLONIZATION; IN-VIVO EFFICACY; ESCHERICHIA-COLI; STAPHYLOCOCCUS-AUREUS; BACTERIOPHAGE THERAPY; VIRULENT BACTERIOPHAGE; BROILER-CHICKENS; INFECTION;
D O I
10.3390/antibiotics10040421
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
To overcome the obstacle of antimicrobial resistance, researchers are investigating the use of phage therapy as an alternative and/or supplementation to antibiotics to treat and prevent infections both in humans and in animals. In the first part of this review, we describe the unique biological characteristics of bacteriophages and the crucial aspects influencing the success of phage therapy. However, despite their efficacy and safety, there is still no specific legislation that regulates their use. In the second part of this review, we describe the comprehensive research done in the past and recent years to address the use of phage therapy for the treatment and prevention of bacterial disease affecting domestic animals as an alternative to antibiotic treatments. While in farm animals, phage therapy efficacy perspectives have been widely studied in vitro and in vivo, especially for zoonoses and diseases linked to economic losses (such as mastitis), in pets, studies are still few and rather recent.
引用
收藏
页数:21
相关论文
共 104 条
  • [71] Public health risk of antimicrobial resistance transfer from companion animals
    Pomba, Constanca
    Rantala, Merja
    Greko, Christina
    Baptiste, Keith Edward
    Catry, Boudewijn
    van Duijkeren, Engeline
    Mateus, Ana
    Moreno, Miguel A.
    Pyorala, Satu
    Ruzauskas, Modestas
    Sanders, Pascal
    Teale, Christopher
    Threlfall, E. John
    Kunsagi, Zoltan
    Torren-Edo, Jordi
    Jukes, Helen
    Torneke, Karolina
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, 72 (04) : 957 - 968
  • [72] The bacteriophage in relation to salmonella pullora infection in the domestic fowl
    Pyle, NJ
    [J]. JOURNAL OF BACTERIOLOGY, 1926, 12 (04) : 245 - 261
  • [73] Isolation, Characterization, and Antibacterial Activity of Bacteriophages Against Methicillin-Resistant Staphylococcus aureus in Pakistan
    Rasool, Muhammad Hidayat
    Yousaf, Rukhsana
    Siddique, Abu Baker
    Saqalein, Muhammad
    Khurshid, Mohsin
    [J]. JUNDISHAPUR JOURNAL OF MICROBIOLOGY, 2016, 9 (10)
  • [74] Ricci A, 2018, EFSA J, V16, DOI [10.2903/j.efsa.2018.5134, 10.2903/j.efsa.2018.5500]
  • [75] Phage Biocontrol of Campylobacter jejuni in Chickens Does Not Produce Collateral Effects on the Gut Microbiota
    Richards, Philip J.
    Connerton, Phillippa L.
    Connerton, Ian F.
    [J]. FRONTIERS IN MICROBIOLOGY, 2019, 10
  • [76] Roach D.R., 2015, Bacteriophage, V5, DOI [10.1080/21597081.2015.1062590, DOI 10.1080/21597081.2015.1062590]
  • [77] ISOLATION AND CHARACTERIZATION OF A NEW BACTERIOPHAGE, CP-1, INFECTING STREPTOCOCCUS-PNEUMONIAE
    RONDA, C
    LOPEZ, R
    GARCIA, E
    [J]. JOURNAL OF VIROLOGY, 1981, 40 (02) : 551 - 559
  • [78] Synergistic phage-antibiotic combinations for the control of Escherichia coli biofilms in vitro
    Ryan, Elizabeth M.
    Alkawareek, Mahmoud Y.
    Donnelly, Ryan F.
    Gilmore, Brendan F.
    [J]. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2012, 65 (02): : 395 - 398
  • [79] Direct Feeding of Microencapsulated Bacteriophages to Reduce Salmonella Colonization in Pigs
    Saez, Anthea C.
    Zhang, Jiayi
    Rostagno, Marcos H.
    Ebner, Paul D.
    [J]. FOODBORNE PATHOGENS AND DISEASE, 2011, 8 (12) : 1269 - 1274
  • [80] Synergistic streptococcal phage λSA2 and B30 endolysins kill streptococci in cow milk and in a mouse model of mastitis
    Schmelcher, Mathias
    Powell, Anne M.
    Camp, Mary J.
    Pohl, Calvin S.
    Donovan, David M.
    [J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2015, 99 (20) : 8475 - 8486