Phage Therapy in Veterinary Medicine

被引:46
作者
Loponte, Rosa [1 ]
Pagnini, Ugo [1 ]
Iovane, Giuseppe [1 ]
Pisanelli, Giuseppe [1 ]
机构
[1] Univ Naples Federico II, Dept Vet Med & Anim Prod, Via Federico Delpino 1, I-80137 Naples, Italy
来源
ANTIBIOTICS-BASEL | 2021年 / 10卷 / 04期
关键词
alternative to antibiotics; bacteriophages; phage therapy; veterinary medicine; pets; CAMPYLOBACTER-JEJUNI COLONIZATION; RESISTANT PSEUDOMONAS-AERUGINOSA; REDUCE SALMONELLA COLONIZATION; IN-VIVO EFFICACY; ESCHERICHIA-COLI; STAPHYLOCOCCUS-AUREUS; BACTERIOPHAGE THERAPY; VIRULENT BACTERIOPHAGE; BROILER-CHICKENS; INFECTION;
D O I
10.3390/antibiotics10040421
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
To overcome the obstacle of antimicrobial resistance, researchers are investigating the use of phage therapy as an alternative and/or supplementation to antibiotics to treat and prevent infections both in humans and in animals. In the first part of this review, we describe the unique biological characteristics of bacteriophages and the crucial aspects influencing the success of phage therapy. However, despite their efficacy and safety, there is still no specific legislation that regulates their use. In the second part of this review, we describe the comprehensive research done in the past and recent years to address the use of phage therapy for the treatment and prevention of bacterial disease affecting domestic animals as an alternative to antibiotic treatments. While in farm animals, phage therapy efficacy perspectives have been widely studied in vitro and in vivo, especially for zoonoses and diseases linked to economic losses (such as mastitis), in pets, studies are still few and rather recent.
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页数:21
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