Vasoactive intestinal contractor/endothelin-2 gene expression in the murine central nervous system

被引：17

作者：

Masuo, Y

Ishikawa, Y

Kozakai, T

Uchide, T

Komatsu, Y

Saida, K

机构：

[1] AIST, Int Patent Organism Depositary, Tsukuba, Ibaraki 3058566, Japan

[2] New Energy & Ind Technol Dev Org, NEDO, Toshima Ku, Tokyo 1706028, Japan

[3] AIST, Inst Mol & Cell Biol, Tsukuba, Ibaraki 3058566, Japan

[4] Kitasato Univ, Sch Vet Med & Anim Sci, Dept Toxicol, Towada, Aomori 0348628, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 300卷 / 03期

关键词：

vasoactive intestinal contractor; endothelin; real-time quantitative reverse transcription-linked polymerase chain reaction; distribution; rat; mouse; brain; pituitary gland; medulla oblongata; cold injury;

D O I：

10.1016/S0006-291X(02)02872-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vasoactive intestinal contractor (VIC) is a member of the endothelin (ET) family. We have investigated the regional distribution of VIC/ET-2 and of ET-1 gene expression in the adult murine brain and pituitary gland. We used real-time quantitative reverse transcription-linked polymerase chain reaction. VIC/ET-2 gene expression was observed at high levels in the pituitary gland and medulla oblongata in both the mouse and rat. Moderate to low levels of expression were observed in other brain regions. On the contrary, ET-1 gene expression was quite low in the pituitary gland in comparison with the levels observed in the cerebral cortex, striatum, and midbrain. Cold injury to the mouse cerebral cortex caused a significant decrease in VIC/ET-2 gene expression in this structure, whilst expression of the ET-1 gene was increased. These results suggest that VIC/ET-2 may have certain physiological roles that differ from those of ET-1 in the brain and pituitary gland. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：661 / 668

页数：8

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