MARVEL:: a conserved domain involved in membrane apposition events

被引：192
作者：
Sánchez-Pulido, L
Martín-Belmonte, F
Valencia, A
Alonso, MA
机构：
[1] CSIC, CNB, Prot Design Grp, E-28049 Madrid, Spain
[2] UAM, CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 12期
关键词：
D O I：
10.1016/S0968-0004(02)02229-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MARVEL is a novel domain with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families. Association with specialized membrane microdomains has been reported for some of these MARVEL domain-containing proteins. Their function could be related to cholesterol-rich membrane apposition events in a variety of cellular processes, such as biogenesis of vesicular transport carriers or tight junction regulation. The MARVEL domain appears to be related to complex human diseases, such as schizophrenia and inflammation.
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收藏
页码：599 / 601
页数：3
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