Systems biology of lipid metabolism: From yeast to human

被引：86

作者：

Nielsen, Jens ^{[1
]}

机构：

[1] Chalmers Univ Technol, Dept Chem & Biol Engn, SE-41296 Gothenburg, Sweden

来源：

FEBS LETTERS | 2009年 / 583卷 / 24期

关键词：

Systems biology; Lipid metabolism; Yeast; Metabolic model; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTORS; PHOSPHOLIPID BIOSYNTHESIS; NETWORKS REVEALS; FATTY-ACID; RECONSTRUCTION; MODELS; GENE; VALIDATION; EXPRESSION;

D O I：

10.1016/j.febslet.2009.10.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid metabolism is highly relevant as it plays a central role in a number of human diseases. Due to the highly interactive structure of lipid metabolism and its regulation, it is necessary to apply a holistic approach, and systems biology is therefore well suited for integrated analysis of lipid metabolism. In this paper it is demonstrated that the yeast Saccharomyces cerevisiae serves as an excellent model organism for studying the regulation of lipid metabolism in eukaryotes as most of the regulatory structures in this part of the metabolism are conserved between yeast and mammals. Hereby yeast systems biology can assist to improve our understanding of how lipid metabolism is regulated. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3905 / 3913

页数：9

共 50 条

[41] Epigenetic Factors and Mitochondrial Biology in Yeast: A New Paradigm for the Study of Cancer Metabolism?
Stoppacciaro, Antonella
Di Vito, Serena
Filetici, Patrizia
[J]. FRONTIERS IN PHARMACOLOGY, 2018, 9
[42] Synthetic Biology for Engineering Acetyl Coenzyme A Metabolism in Yeast
Nielsen, Jens
[J]. MBIO, 2014, 5 (06):
[43] Nutritional Systems Biology: Definitions and Approaches
Panagiotou, Gianni
Nielsen, Jens
[J]. ANNUAL REVIEW OF NUTRITION, 2009, 29 : 329 - 339
[44] Effects of MCHM on yeast metabolism
Pupo, Amaury
Ku, Kang Mo
Gallagher, Jennifer E. G.
[J]. PLOS ONE, 2019, 14 (10):
[45] Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases
Hussain, Yusuf
Dar, Mohammad Irfan
Pan, Xiaoyue
[J]. METABOLITES, 2024, 14 (12)
[46] Proteomics and systems biology to tackle biological complexity: Yeast as a case study
Alberghina, Lilia
Cirulli, Claudia
[J]. PROTEOMICS, 2010, 10 (24) : 4337 - 4341
[47] Systems biology analysis of G protein and MAP kinase signaling in yeast
N Hao
M Behar
T C Elston
H G Dohlman
[J]. Oncogene, 2007, 26 : 3254 - 3266
[48] A systems biology approach to the mutual interaction between yeast and the immune system
Rizzetto, Lisa
Cavalieri, Duccio
[J]. IMMUNOBIOLOGY, 2010, 215 (9-10) : 762 - 769
[49] Systems biology analysis of G protein and MAP kinase signaling in yeast
Hao, N.
Behar, M.
Elston, T. C.
Dohlman, H. G.
[J]. ONCOGENE, 2007, 26 (22) : 3254 - 3266
[50] Oleaginous Yeast Biology Elucidated With Comparative Transcriptomics
Weintraub, Sarah J.
Li, Zekun
Nakagawa, Carter L.
Collins, Joseph H.
Young, Eric M.
[J]. BIOTECHNOLOGY AND BIOENGINEERING, 2025, 122 (03) : 677 - 697

← 1 2 3 4 5 →