Microbial hydroxylation of cinobufagin by Mucor spinosus

被引：11

作者：

Zhang, W

Ye, M

Qu, GQ

Wu, WY

Chen, YJ

Guo, DA ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Shenyang Phrmaceut Univ, Shenyang, Liaoning, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2005年 / 7卷 / 03期

基金：

中国国家自然科学基金;

关键词：

biotransformation; cinobufagin; Mucor spinosus;

D O I：

10.1080/10286020410001690136

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Mucor spinosus has been employed for the biotransformation of cinobufagin ( 1 ) to afford three metabolites. On the basis of their physico-chemical data, the structures of the transformation products have been characterized as 1beta-hydroxy-cinobufagin ( 2 ), 12beta-hydroxy-cinobufagin ( 3 ) and 1beta,12beta-dihydroxy-cinobufagin ( 4 ), of which metabolites 2 and 4 are new compounds. In vitro cytotoxic activities of the biotransformation products and the substrate-cinobufagin have been assayed against four tumor cell lines of Bel 7420, BGC 823, HeLa and HL 60; they all showed cytotoxic activities.

引用

页码：225 / 229

页数：5

共 13 条

[1] Regio- and stereo-selective biotransformation of 2α,5α,10β,14β-tetra-acetoxy-4(20), 11-taxadiene by Ginkgo cell suspension cultures [J].