The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine

被引：79
作者：
Ahmadian, Elham [1 ,2 ,3 ]
Dizaj, Solmaz Maleki [1 ]
Eftekhari, Aziz [4 ]
Dalir, Elaheh [5 ]
Vahedi, Parviz [4 ]
Hasanzadeh, Amir [4 ]
Samiei, Mohammad [6 ]
机构：
[1] Tabriz Univ Med Sci, Dent & Periodontal Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Stem Cell & Regenerat Med Inst, Tabriz, Iran
[3] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran
[4] Maragheh Univ Med Sci, Maragheh, Iran
[5] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Biomed Inst, Tabriz, Iran
[6] Tabriz Univ Med Sci, Fac Dent, Tabriz, Iran
来源：
DRUG RESEARCH | 2020年 / 70卷 / 01期
关键词：
regenerative medicine; drug delivery; biopharmaceuticals; STEM-CELL; TISSUE; ENCAPSULATION; RELEASE; CHONDROCYTES; FIBROBLASTS; MODEL;
D O I：
10.1055/a-0991-7585
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.
引用
收藏
页码：6 / 11
页数：6
相关论文
共 45 条
  • [1] New directions in photopolymerizable biomaterials
    Anseth, KS
    Burdick, JA
    [J]. MRS BULLETIN, 2002, 27 (02) : 130 - 136
  • [2] Hyaluronic Acid Hydrogels for Biomedical Applications
    Burdick, Jason A.
    Prestwich, Glenn D.
    [J]. ADVANCED MATERIALS, 2011, 23 (12) : H41 - H56
  • [3] Engineered Microenvironments for Controlled Stem Cell Differentiation
    Burdick, Jason A.
    Vunjak-Novakovic, Gordana
    [J]. TISSUE ENGINEERING PART A, 2009, 15 (02) : 205 - 219
  • [4] Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor
    Cai, SS
    Liu, YC
    Shu, XZ
    Prestwich, GD
    [J]. BIOMATERIALS, 2005, 26 (30) : 6054 - 6067
  • [5] Biomedical applications of hydrogels: A review of patents and commercial products
    Calo, Enrica
    Khutoryanskiy, Vitaliy V.
    [J]. EUROPEAN POLYMER JOURNAL, 2015, 65 : 252 - 267
  • [6] Chung C, 2008, TISSUE ENG PT A, V14, P1121, DOI [10.1089/ten.tea.2007.0291, 10.1089/tea.2007.0291]
  • [7] Influence of gel properties on neocartilage formation by auricular chondrocytes photoencapsulated in hyaluronic acid networks
    Chung, Cindy
    Mesa, John
    Randolph, Mark A.
    Yaremchuk, Michael
    Burdick, Jason A.
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 77A (03) : 518 - 525
  • [8] Microwave-Assisted Hydrogel Synthesis: A New Method for Crosslinking Polymers in Aqueous Solutions
    Cook, Joseph P.
    Goodall, Glenn W.
    Khutoryanskaya, Olga V.
    Khutoryanskiy, Vitaliy V.
    [J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2012, 33 (04) : 332 - 336
  • [9] Development of Injectable Hyaluronic Acid/Cellulose Nanocrystals Bionanocomposite Hydrogels for Tissue Engineering Applications
    Domingues, Rui M. A.
    Silva, Marta
    Gershovich, Pavel
    Betta, Sefano
    Babo, Pedro
    Caridade, Sofia G.
    Mano, Joao F.
    Motta, Antonella
    Reis, Rui L.
    Gomes, Manuela E.
    [J]. BIOCONJUGATE CHEMISTRY, 2015, 26 (08) : 1571 - 1581
  • [10] Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery
    Donnelly, Ryan F.
    Singh, Thakur Raghu Raj
    Garland, Martin J.
    Migalska, Katarzyna
    Majithiya, Rita
    McCrudden, Cian M.
    Kole, Prashant Laxman
    Mahmood, Tuan Mazlelaa Tuan
    McCarthy, Helen O.
    Woolfson, A. David
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2012, 22 (23) : 4879 - 4890
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