Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR

被引：24

作者：

Husak, Michal ^{[1
]}

Kratochvil, Bohumil ^{[1
]}

Jegorov, Alexandr ^{[2
]}

Brus, Jiri ^{[3
]}

Maixner, Jaroslav ^{[4
]}

Rohlicek, Jan ^{[1
]}

机构：

[1] Prague Inst Chem Technol, Dept Solid State Chem, CR-16628 Prague 6, Czech Republic

[2] Teva Czech Ind, Res & Dev, Ceske Budejovice 37005, Czech Republic

[3] Acad Sci Czech Republic, Inst Macromol Chem, CR-16206 Prague 6, Czech Republic

[4] Prague Inst Chem Technol, Cent Labs, CR-16628 Prague 6, Czech Republic

来源：

STRUCTURAL CHEMISTRY | 2010年 / 21卷 / 03期

关键词：

Crystal structure; Simvastatin; Powder diffraction; Solid-state NMR;

D O I：

10.1007/s11224-009-9579-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simvastatin is a substance used for the treatment of hypercholesterolemia. In addition to the already known room temperature structure of simvastatin (ejka et al. in Acta Cryst C59:o428, 2003) two new low-temperature polymorphs were found by X-ray powder diffraction with the phase transition at 261 and 223 K (later confirmed by DSC to be 272 and 232 K). The main differences among three polymorphs consist in the side-chains conformation only and the phase changes are fully reversible. The structures of the polymorphs were studied by the powder diffraction based on synchrotron radiation as well as by solid-state NMR spectroscopy.

引用

页码：511 / 518

页数：8

共 24 条

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