Synthesis and Anti-Tubercular (Tb) Evaluation of Bis[4-Ethylidineamino[1,2,4]Triazole-3-Thiol] Tethered by 1,4-Dihydropyridine

被引：8

作者：

Abu-Melha, S. ^{[1
]}

Edrees, M. M. ^{[1
,2
]}

Kheder, N. A. ^{[3
]}

Saad, A. M. ^{[4
]}

Riyadh, S. M. ^{[3
,5
]}

Abdel-Aziz, M. M. ^{[6
]}

Abdelmoaz, M. A. ^{[7
]}

Gomha, S. M. ^{[3
,8
]}

机构：

[1] King Khalid Univ, Dept Chem, Fac Sci, Abha 61413, Saudi Arabia

[2] Natl Org Drug Control & Res NODCAR, Dept Organ Chem, Giza 12311, Egypt

[3] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt

[4] King Khalid Univ, Dept Pharmaceut Chem, Fac Pharm, Abha 61441, Saudi Arabia

[5] Taibah Univ, Dept Chem, Fac Sci, Al Madinah Al Munawarah 30002, Saudi Arabia

[6] Al Azhar Univ, Reg Ctr Mycol & Biotechnol, Cairo 11754, Egypt

[7] Sinai Univ, Dept Pharmaceut Chem, Fac Pharm, Al Arish 16020, Egypt

[8] Islamic Univ Madinah, Dept Chem, Fac Sci, Madinah 42351, Saudi Arabia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2022年 / 48卷 / 02期

关键词：

1,4-dihydropyridine; bis[1,2,4]triazole; Schiff base; condensation reaction; anti-tubercular activity; MYCOBACTERIUM-TUBERCULOSIS; ANTIBACTERIAL ACTIVITIES; DESIGN; DERIVATIVES; GATIFLOXACIN; THIAZOLE;

D O I：

10.1134/S1068162022020029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of 5,5'-(2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-diyl)bis[4-(ethylideneamino)-4H-[1,2,4]-triazole-3-thiol) was synthesized via keto-imine condensation. The structural elucidation of the products was investigated by spectral and elemental techniques. Also, the newly synthesized compounds were evaluated for their in vitro anti-tubercular activity, the sensitive and resistant Mycobacterium tuberculosis. Among sixteen tested compounds, compound (V) is equipotent to the standard drug isoniazid against sensitive Mycobacterium tuberculosis, while compounds (IXb), (VIId), and (IIIf) have promising activity.

引用

页码：345 / 352

页数：8

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