LC3 and Beclin-1 as Markers of Autophagic Activity in Breast Cancer

被引：2
作者：
Nurdinov, Nursultan [1 ,2 ]
Cinar, Venhar [1 ,2 ]
Guler, Ahsen [1 ,2 ]
Yilmaz, Sevda Gokce [1 ,2 ]
Kokcu, Nesrin Delibasi [1 ,2 ]
Hamurcu, Zuhal [1 ,2 ]
机构：
[1] Erciyes Univ, Betul Ziya Eren Genome & Stem Cell Ctr, Kayseri, Turkey
[2] Erciyes Univ, Fac Med, Dept Med Biol, Kayseri, Turkey
来源：
ERCIYES MEDICAL JOURNAL | 2021年 / 43卷 / 04期
关键词：
Autophagy; beclin-1; breast cancer; LC3; siRNA; POOR-PROGNOSIS; CELL-DEATH; EXPRESSION; INHIBITION; BECN1; PROLIFERATION; RESISTANCE; MIGRATION; SURVIVAL; GROWTH;
D O I：
10.14744/etd.2020.99997
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autophagy is a catabolic pathway meaning "self-eating" that facilitates nutrient recycling from damaged and aged organelles and other impaired cellular components through lysosomal degradation. Regulation of this process has been associated with the development of cancer. It can play different roles at different tumors and developmental stages of tumors. In breast cancer, similarly, autophagy functions as a mechanism promoting survival or leading to death. Whereas, it is very important to define the role of autophagy as an effective treatment strategy in breast cancer cells. Therefore, in this review, the role of inhibited autophagy is discussed with specific RNAs targeting Beclin-1 and LC3 genes in breast cancer.
引用
收藏
页码：325 / 328
页数：4
相关论文
共 40 条
  • [1] Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells
    Akar, Ugur
    Chaves-Reyez, Arturo
    Barria, Magaly
    Tari, Ana
    Sanguino, Angela
    Kondo, Yasuko
    Kondo, Seiji
    Arun, Banu
    Lopez-Berestein, Gabriel
    Ozpolat, Bulent
    [J]. AUTOPHAGY, 2008, 4 (05) : 669 - 679
  • [2] From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment
    Cerella, Claudia
    Teiten, Marie-Helene
    Radogna, Flavia
    Dicato, Mario
    Diederich, Marc
    [J]. BIOTECHNOLOGY ADVANCES, 2014, 32 (06) : 1111 - 1122
  • [3] Decreased expression of autophagy protein LC3 and sternness (CD44+/CD24-/low) indicate poor prognosis in triple-negative breast cancer
    Chang, Shu-Jyuan
    Ou-Yang, Fu
    Tu, Hung-Pin
    Lin, Chih-Hung
    Huang, Shu-Hung
    Kostoro, Joanna
    Hou, Ming-Feng
    Chai, Chee-Yin
    Kwan, Aij-Lie
    [J]. HUMAN PATHOLOGY, 2016, 48 : 48 - 55
  • [4] Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer
    Chittaranjan, Suganthi
    Bortnik, Svetlana
    Dragowska, Wieslawa H.
    Xu, Jing
    Abeysundara, Namal
    Leung, Amy
    Go, Nancy E.
    DeVorkin, Lindsay
    Weppler, Sherry A.
    Gelmon, Karen
    Yapp, Donald T.
    Bally, Marcel B.
    Gorski, Sharon M.
    [J]. CLINICAL CANCER RESEARCH, 2014, 20 (12) : 3159 - 3173
  • [5] Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity
    Cicchini, Michelle
    Chakrabarti, Rumela
    Kongara, Sameera
    Price, Sandy
    Nahar, Ritu
    Lozy, Fred
    Zhong, Hua
    Vazquez, Alexei
    Kang, Yibin
    Karantza, Vassiliki
    [J]. AUTOPHAGY, 2014, 10 (11) : 2036 - 2052
  • [6] Pro-survival autophagy: An emerging candidate of tumor progression through maintaining hallmarks of cancer
    Das, Chandan Kanta
    Banerjee, Indranil
    Mandal, Mahitosh
    [J]. SEMINARS IN CANCER BIOLOGY, 2020, 66 : 59 - 74
  • [7] Autophagy-dependent cell death
    Denton, Donna
    Kumar, Sharad
    [J]. CELL DEATH AND DIFFERENTIATION, 2019, 26 (04) : 605 - 616
  • [8] Low expression of Beclin 1 and elevated expression of HIF-1α refine distant metastasis risk and predict poor prognosis of ER-positive, HER2-negative breast cancer
    Dong, Min
    Wan, Xiang-bo
    Yuan, Zhong Yu
    Wei, Li
    Fan, Xin Juan
    Wang, Tian-tian
    Lv, Yan Chun
    Li, Xing
    Chen, Zhan-hong
    Chen, Jie
    Lin, Qu
    Wen, Jing-yun
    Ma, Xiao-kun
    Liu, Quentin
    Wu, Xiang Yuan
    [J]. MEDICAL ONCOLOGY, 2013, 30 (01)
  • [9] The multifaceted role of autophagy in cancer and the microenvironment
    Folkerts, Hendrik
    Hilgendorf, Susan
    Vellenga, Edo
    Bremer, Edwin
    Wiersma, Valerie R.
    [J]. MEDICINAL RESEARCH REVIEWS, 2019, 39 (02) : 517 - 560
  • [10] FOXM1 plays a role in autophagy by transcriptionally regulating Beclin-1 and LC3 genes in human triple-negative breast cancer cells
    Hamurcu, Zuhal
    Delibasi, Nesrin
    Nalbantoglu, Ufuk
    Sener, Elif Funda
    Nurdinov, Nursultan
    Tasci, Bayram
    Taheri, Serpil
    Ozkul, Yusuf
    Donmez-Altuntas, Hamiyet
    Canatan, Halit
    Ozpolat, Bulent
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2019, 97 (04): : 491 - 508
1234