The inherited genetics of ovarian and endometrial cancer

被引：58

作者：

Gayther, Simon A. ^{[1
]}

Pharoah, Paul D. P. ^{[2
,3
]}

机构：

[1] UCL, EGA Inst Womens Hlth, Gynaecol Canc Res Labs, London, England

[2] Univ Cambridge, Strangeways Res Lab, Dept Oncol, Cambridge, England

[3] Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 03期

关键词：

NONPOLYPOSIS COLORECTAL-CANCER; SINGLE NUCLEOTIDE POLYMORPHISMS; GENOME-WIDE ASSOCIATION; FAMILY-HISTORY; LYNCH SYNDROME; BRCA2; MUTATIONS; RISK; SUSCEPTIBILITY; BREAST; POPULATION;

D O I：

10.1016/j.gde.2010.03.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endometrial and epithelial ovarian cancers are the fourth and fifth most common cancers in women in developed countries, after breast, lung, and colorectal cancer. In the United States alone, in 2008 there were about 40 000 new diagnoses of endometrial cancer and 7500 disease-related deaths. For ovarian cancer, there were about 22 000 new diagnoses and 15 000 deaths over the same period. The purpose of this article is to review the recent developments in the inherited genetics of ovarian and endometrial cancer, with particular attention to recent progress in identifying common low-penetrance susceptibility genes and their clinical implications.

引用

页码：231 / 238

页数：8

共 56 条

[1]

AAMIO M, 1999, INT J CANCER, V81, P214

[2] Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history:: A combined analysis of 22 studies [J].

Antoniou, A ;

Pharoah, PDP ;

Narod, S ;

Risch, HA ;

Eyfjord, JE ;

Hopper, JL ;

Loman, N ;

Olsson, H ;

Johannsson, O ;

Borg, Å ;

Pasini, B ;

Radice, P ;

Manoukian, S ;

Eccles, DM ;

Tang, N ;

Olah, E ;

Anton-Culver, H ;

Warner, E ;

Lubinski, J ;

Gronwald, J ;

Gorski, B ;

Tulinius, H ;

Thorlacius, S ;

Eerola, H ;

Nevanlinna, H ;

Syrjäkoski, K ;

Kallioniemi, OP ;

Thompson, D ;

Evans, C ;

Peto, J ;

Lalloo, F ;

Evans, DG ;

Easton, DF .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) :1117-1130

[3] Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation:: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics [J].

Antoniou, A. C. ;

Hardy, R. ;

Walker, L. ;

Evans, D. G. ;

Shenton, A. ;

Eeles, R. ;

Shanley, S. ;

Pichert, G. ;

Izatt, L. ;

Rose, S. ;

Douglas, F. ;

Eccles, D. ;

Morrison, P. J. ;

Scott, J. ;

Zimmern, R. L. ;

Easton, D. F. ;

Pharoah, P. D. P. .

JOURNAL OF MEDICAL GENETICS, 2008, 45 (07) :425-431

[4] Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers [J].

Antoniou, Antonis C. ;

Spurdle, Amanda B. ;

Sinilnikova, Olga M. ;

Healey, Sue ;

Pooley, Karen A. ;

Schmutzler, Rita K. ;

Versmold, Beatrix ;

Engel, Christoph ;

Meindl, Alfons ;

Arnold, Norbert ;

Hofmann, Wera ;

Sutter, Christian ;

Niederacher, Dieter ;

Deissler, Helmut ;

Caldes, Trinidad ;

Kampjarvi, Kati ;

Nevanlinna, Heli ;

Simard, Jacques ;

Beesley, Jonathan ;

Chen, Xiaoqing ;

Neuhausen, Susan L. ;

Rebbeck, Timothy R. ;

Wagner, Theresa ;

Lynch, Henry T. ;

Isaacs, Claudine ;

Weitzel, Jeffrey ;

Ganz, Patricia A. ;

Daly, Mary B. ;

Tomlinson, Gail ;

Olopade, Olufunmilayo I. ;

Bium, Joanne L. ;

Couch, Fergus J. ;

Peterlongo, Paolo ;

Manoukian, Siranoush ;

Barile, Monica ;

Radice, Paolo ;

Szabo, Csilla I. ;

Pereira, Lutecia H. Mateus ;

Greene, Mark H. ;

Rennert, Gad ;

Leibkowicz, Flavio ;

Barnett-Griness, Ofra ;

Andrulis, Irene L. ;

Ozcelik, Hilmi ;

Gerdes, Anne-Marie ;

Caligo, Maria A. ;

Laitman, Yael ;

Kaufman, Bella ;

Milgrom, Roni ;

Friedman, Eitan .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (04) :937-948

[5] RAD51 135G→C modifies breast cancer risk among BRCA2 mutation carriers:: Results from a combined analysis of 19 studies [J].

Antoniou, Antonis C. ;

Sinilnikova, Olga M. ;

Simard, Jacques ;

Leone, Melanie ;

Dumont, Martine ;

Neuhausen, Susan L. ;

Struewing, Jeffery P. ;

Stoppa-Lyonnet, Dominique ;

Barjhoux, Laure ;

Hughes, David J. ;

Coupier, Isabelle ;

Belotti, Muriel ;

Lasset, Christine ;

Rebbeck, Timothy R. ;

Wagner, Theresa ;

Lynch, Henry T. ;

Domchek, Susan M. ;

Nathanson, Katherine L. ;

Garber, Judy E. ;

Weitzel, Jeffrey ;

Narod, Steven A. ;

Tomlinson, Gail ;

Olopade, Olufunmilayo I. ;

Godwin, Andrew ;

Isaacs, Claudine ;

Jakubowska, Anna ;

Lubinski, Jan ;

Gronwald, Jacek ;

Gorski, Bohdan ;

Byrski, Tomasz ;

Huzarski, Tomasz ;

Peock, Susan ;

Cook, Margaret ;

Baynes, Caroline ;

Murray, Alexandra ;

Rogers, Mark ;

Daly, Peter A. ;

Dorkins, Huw ;

Schmutzler, Rita K. ;

Versmold, Beatrix ;

Engel, Christoph ;

Meindl, Alfons ;

Arnold, Norbert ;

Niederacher, Dieter ;

Deissler, Helmut ;

Spurdle, Amanda B. ;

Chen, Xiaoqing ;

Waddell, Nicola ;

Cloonan, Nicole ;

Kirchhoff, Tomas .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (06) :1186-1200

[6]

Antoniou Antonis C, 2006, Future Oncol, V2, P257, DOI 10.2217/14796694.2.2.257

[7] Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers [J].

Baglietto, Laura ;

Lindor, Noralane M. ;

Dowty, James G. ;

White, Darren M. ;

Wagner, Anja ;

Garcia, Encarna B. Gomez ;

Vriends, Annette H. J. T. ;

Cartwright, Nicola R. ;

Barnetson, Rebecca A. ;

Farrington, Susan M. ;

Tenesa, Albert ;

Hampel, Heather ;

Buchanan, Daniel ;

Arnold, Sven ;

Young, Joanne ;

Walsh, Michael D. ;

Jass, Jeremy ;

Macrae, Finlay ;

Antill, Yoland ;

Winship, Ingrid M. ;

Giles, Graham G. ;

Goldblatt, Jack ;

Parry, Susan ;

Suthers, Graeme ;

Leggett, Barbara ;

Butz, Malinda ;

Aronson, Melyssa ;

Poynter, Jenny N. ;

Baron, John A. ;

Le Marchand, Loic ;

Haile, Robert ;

Gallinger, Steve ;

Hopper, John L. ;

Potter, John ;

de la Chapelle, Albert ;

Vasen, Hans F. ;

Dunlop, Malcolm G. ;

Thibodeau, Stephen N. ;

Jenkins, Mark A. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2010, 102 (03) :193-201

[8]

BALMANA J, 2008, ASCO ED BOOK 2008, P59

[9]

Berchuck A, 2008, ADV EXP MED BIOL, V622, P53, DOI 10.1007/978-0-387-68969-2_5

[10] Toward new strategies to select young endometrial cancer patients for mismatch repair gene mutation analysis [J].

Berends, MJW ;

Wu, Y ;

Sijmons, RH ;

van der Sluis, T ;

Ek, WB ;

Ligtenberg, MJL ;

Arts, NJW ;

ten Hoor, KA ;

Kleibeuker, JH ;

de Vries, EGE ;

Mourits, MJE ;

Hollema, H ;

Buys, CHCM ;

Hofstra, RMW ;

van der Zee, AGJ .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (23) :4364-4370

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