Association between expression of long noncoding RNAs in placenta and pregnancy features

被引：4
作者：
Pouresmaeili, Farkhondeh [1 ]
Azari, Iman [1 ]
Arsang-Jang, Shahram [2 ]
Taheri, Mohammad [2 ,3 ]
Ghafouri-Fard, Soudeh [1 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran
[2] Qom Univ Med Sci, Clin Res Dev Ctr CRDU, Qom, Iran
[3] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran
来源：
PERSONALIZED MEDICINE | 2019年 / 16卷 / 06期
关键词：
CCAT2; expression; FAS-AS1; gestational age; IUGR; lncRNA; maternal age; OIP5-AS1; placenta; UCA1; INTRAUTERINE GROWTH RESTRICTION; BIRTH-WEIGHT; CANCER; PARITY;
D O I：
10.2217/pme-2018-0078
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: The contribution of long noncoding RNAs (lncRNAs) has been highlighted in a variety of human disorders including cancer and placenta-associated conditions. Methods: We evaluated expression of CCAT2, UCA1, FAS-AS1 and OIP5-AS1 lncRNAs in placenta samples obtained from normal and intrauterine growth restriction pregnancies. Results: There was no significant difference in expression of these lncRNAs between cases and controls. A significant association was found between CCAT2 expression and gravidity/parity. CCAT2 expression was higher in cases with abortion history. Cases who received folic acid had lower expression of this lncRNA. Conclusion: The current study provides evidences for association between expression of CCAT2 and clinical determinants of placenta function. Future studies are needed to elaborate the underlying mechanism.
引用
收藏
页码：457 / 466
页数：10
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