A one-generation reproductive toxicity study of the mycotoxin ochratoxin A in Fischer rats

被引：16

作者：

Bondy, G. S. ^{[1
]}

Curran, I. H. C. ^{[1
]}

Coady, L. C. ^{[1
]}

Armstrong, C. ^{[1
]}

Bourque, C. ^{[1
]}

Bugiel, S. ^{[1
]}

Caldwell, D. ^{[1
]}

Kwong, K. ^{[2
]}

Lefebvre, D. E. ^{[1
]}

Maurice, C. ^{[3
]}

Marchetti, F. ^{[3
]}

Pantazopoulos, P. P. ^{[2
]}

Ross, N. ^{[1
]}

Gannon, A. M. ^{[1
]}

机构：

[1] Hlth Canada, Bur Chem Safety, Food Directorate, Hlth Prod & Food Branch, Ottawa, ON K1A 0K9, Canada

[2] Ontario Food Lab, Regulatory Operat & Enforcement Branch, Labs Directorate, Toronto, ON M1P 4R7, Canada

[3] Hlth Canada, Hlth Environm & Consumer Safety Branch, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0K9, Canada

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2021年 / 153卷

关键词：

Ochratoxin; Reproductive toxicology; Fischer rat; Milk; Ovary; Testes; Kidney; MULTI-OOCYTE FOLLICLES; NONPROLIFERATIVE LESIONS; OVARIAN STEROIDOGENESIS; PROLIFERATIVE LESIONS; LABORATORY RAT; EXPOSURE; NEPHROPATHY; BIOMARKERS; EXTRACT; POOL;

D O I：

10.1016/j.fct.2021.112247

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium molds. Grain-based foods account for most human dietary exposures to OTA. OTA is a teratogen, but its reproductive and developmental effects are poorly understood. A one-generation reproductive toxicity study was conducted with groups of 16 male and 16 female Fischer rats exposed to 0, 0.026, 0.064, 0.16, 0.4 or 1.0 mg OTA/kg in diet. Dams exposed to 1.0 mg OTA/kg diet had statistically significant F1 pup losses between implantation and postnatal day (PND 4). Delays in preputial separation (PPS) and vaginal opening (VO) were indicative of delayed puberty in F1 rats. Mild renal lesions in nursing pups indicated that exposure prior to weaning impacted the kidneys. The developing kidney was more susceptible to OTA than the adult kidney. Significant increases in multi-oocyte follicles (MOFs) and proportional changes in resting and growing follicles were observed in F1 female ovaries. Plasma testosterone was reduced in F0 males, and there were negative effects on sperm quality in F0 and F1 male rats. The results confirm that continuous dietary exposure to OTA causes post-implantation fetotoxicity in dams, and renal and reproductive toxicity in their male and female offspring.

引用

页数：14

共 67 条

[1] OPINION OF THE SCIENTIFIC PANEL ON CONTAMINANTS IN THE FOOD CHAIN ON A REQUEST FROM THE COMMISSION RELATED TO OCHRATOXIN A IN FOOD [J].