Post-transcriptional modifications and "Calmodulation" of voltage-gated calcium channel function: Reflections by two collaborators of David T Yue

被引：0

作者：

Soong, Tuck Wah ^{[1
,2
,3
,4
]}

Mori, Masayuki X. ^{[5
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117595, Singapore

[2] NUS Grad Sch Integrat Sci & Engn, Singapore, Singapore

[3] Neurobiol Aging Program, Singapore, Singapore

[4] Natl Inst Neurosci, Singapore, Singapore

[5] Kyoto Univ, Grad Sch Engn, Dept Synthet Chem & Biol Chem, Kyoto, Japan

来源：

CHANNELS | 2016年 / 10卷 / 01期

基金：

日本学术振兴会;

关键词：

alternative splicing; calcium channels; crystal structure; Ca2+-regulation; calmodulin; RNA editing; AUDITORY HAIR-CELLS; TERM SYNAPTIC PLASTICITY; CA2+ CHANNELS; CA(V)1.3 CHANNELS; CA2+-DEPENDENT INACTIVATION; CRYSTAL-STRUCTURE; MOLECULAR SWITCH; IQ DOMAIN; SUBUNIT; FACILITATION;

D O I：

10.1080/19336950.2015.1051271

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review article is written to specially pay tribute to David T. Yue who was an outstanding human being and an excellent scientist who exuded passion and creativity. He exemplified an inter-disciplinary scientist who was able to cross scientific boundaries effortlessly in order to provide amazing understanding on how calcium channels work. This article provides a glimpse of some of the research the authors have the privilege to collaborate with David and it attempts to provide the thinking behind some of the research done. In a wider context, we highlight that calcium channel function could be exquisitely modulated by interaction with a tethered calmodulin. Post-transcriptional modifications such as alternative splicing and RNA editing further influence the Ca2+-CaM mediated processes such as calcium dependent inhibition and/or facilitation. Besides modifications of electrophysiological and pharmacological properties, protein interactions with the channels could also be influenced in a splice-variant dependent manner.

引用

页码：14 / 19

页数：6

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