Isepamicin sulfate-induced sensorineural hearing loss in patients with the 1555 A→G mitochondrial mutation

被引：13
|
作者：
Usami, S [1 ]
Abe, S [1 ]
Tono, T [1 ]
Komune, S [1 ]
Kimberling, WJ [1 ]
Shinkawa, H [1 ]
机构：
[1] Hirosaki Univ, Sch Med, Dept Otorhinolaryngol, Hirosaki, Aomori 036, Japan
来源：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1998年 / 60卷 / 03期
关键词：
isepamicin sulfate; aminoglycoside; ototoxicity; sensorineural hearing loss; mitochondria; point mutation; genetics;
D O I：
10.1159/000027590
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
A mitochondrial mutation at nucleotide 1555 has been reported to be susceptible to aminoglycoside antibiotics as well as one of the causes of nonsyndromic sensorineural hearing loss. We herewith report 2 cases bearing the 1555 A-->G mitochondrial mutation who had hearing loss alter short-term exposure to the new aminoglycoside antibiotic, isepamicin sulfate. Even when using aminoglycoside antibiotics with milder side effects, careful attention should be paid in applying them to patients with particular genetic backgrounds.
引用
收藏
页码：164 / 169
页数：6
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