Decreased lateral geniculate nucleus activation in retrogeniculate hemianopia demonstrated by functional magnetic resonance imaging at 4Tesla

被引：11
|
作者：
Miki, A
Liu, GT
Modestino, EJ
Bonhomme, GR
Liu, CSJ
Haselgrove, JC
机构：
[1] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Ophthalmol, Div Neuroophthalmol, Philadelphia, PA 19104 USA
[3] Childrens Hosp Philadelphia, Funct MRI Res Unit, Philadelphia, PA 19104 USA
来源：
OPHTHALMOLOGICA | 2005年 / 219卷 / 01期
关键词：
homonymous hemianopia; lateral geniculate nucleus; visual cortex; functional magnetic resonance imaging; retrograde degeneration;
D O I：
10.1159/000081776
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Functional magnetic resonance imaging ( fMRI) can detect lateral geniculate nucleus (LGN) activation. We studied LGN function in 5 patients with retrogeniculate homonymous hemianopia using fMRI at 4.0 Tesla during binocular visual stimulation. Decreased activation of visual cortex and LGN on the side of the lesion was observed in all 5 patients. These findings suggest that retrogeniculate lesions are associated with decreased activation of the LGN, due to retrograde degeneration or a functional decrease caused by decreased feedback from ipsilateral visual cortex. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码：11 / 15
页数：5
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