Medicinal Plants with Anti-Leukemic Effects: A Review

被引：47

作者：

Maher, Tahani ^{[1
]}

Ahmad Raus, Raha ^{[1
]}

Daddiouaissa, Djabir ^{[1
,2
]}

Ahmad, Farah ^{[1
]}

Adzhar, Noor Suhana ^{[3
]}

Latif, Elda Surhaida ^{[4
]}

Abdulhafiz, Ferid ^{[5
]}

Mohammed, Arifullah ^{[5
]}

机构：

[1] Int Islamic Univ, Biotechnol Engn Dept, Kulliyyah Engn, Malaysia IIUM, POB 10, Kuala Lumpur 50728, Malaysia

[2] Int Islamic Univ Malaysia IIUM, Int Inst Halal Res & Training INHART, Level 3,KICT Bldg,Jalan Gombak, Kuala Lumpur 53100, Malaysia

[3] Univ Malaysia, Fac Ind Sci & Technol, Pekan Pahang 26600, Kuantan, Malaysia

[4] Univ Kebangsaan Malaysia, Ctr Toxicol & Hlth Risk Studies CORE, Fac Hlth Sci, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia

[5] Univ Malaysia Kelantan, Fac Agrobased Ind, Jeli 17600, Kelantan, Malaysia

来源：

MOLECULES | 2021年 / 26卷 / 09期

关键词：

anti-leukemia; leukemia; medicinal plants; alternative medicine; drug discovery; BONE-MINERAL DENSITY; CELLS IN-VITRO; SALVIA-OFFICINALIS; ANTIPROLIFERATIVE ACTIVITIES; SCUTELLARIA-BAICALENSIS; TITHONIA-DIVERSIFOLIA; CHEMICAL-CONSTITUENTS; LYMPHOCYTIC-LEUKEMIA; ANTIOXIDANT ACTIVITY; ANTICANCER ACTIVITY;

D O I：

10.3390/molecules26092741

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukemia is a leukocyte cancer that is characterized by anarchic growth of immature immune cells in the bone marrow, blood and spleen. There are many forms of leukemia, and the best course of therapy and the chance of a patient's survival depend on the type of leukemic disease. Different forms of drugs have been used to treat leukemia. Due to the adverse effects associated with such therapies and drug resistance, the search for safer and more effective drugs remains one of the most challenging areas of research. Thus, new therapeutic approaches are important to improving outcomes. Almost half of the drugs utilized nowadays in treating cancer are from natural products and their derivatives. Medicinal plants have proven to be an effective natural source of anti-leukemic drugs. The cytotoxicity and the mechanisms underlying the toxicity of these plants to leukemic cells and their isolated compounds were investigated. Effort has been made throughout this comprehensive review to highlight the recent developments and milestones achieved in leukemia therapies using plant-derived compounds and the crude extracts from various medicinal plants. Furthermore, the mechanisms of action of these plants are discussed.

引用

页数：25

共 156 条

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