Intercellular Transportation of Quantum Dots Mediated by Membrane Nanotubes

被引：58

作者：

He, Kangmin ^{[2
,3
]}

Luo, Wangxi ^{[1
]}

Zhang, Yuliang ^{[1
]}

Liu, Fei ^{[2
,3
]}

Liu, Da ^{[1
]}

Xu, Li ^{[1
]}

Qin, Lei ^{[2
,3
]}

Xiong, Chunyang ^{[2
,3
]}

Lu, Zhizhen ^{[2
,3
]}

Fang, Xiaohong ^{[1
]}

Zhang, Youyi ^{[2
,3
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[2] Peking Univ, Minist Educ Key Lab Mol Cardiovasc Sci, Hosp 3, Acad Adv Interdisciplinary Studies, Beijing 100191, Peoples R China

[3] Peking Univ, Minist Educ Key Lab Mol Cardiovasc Sci, Hosp 3, Inst Vasc Med, Beijing 100191, Peoples R China

来源：

ACS NANO | 2010年 / 4卷 / 06期

基金：

中国国家自然科学基金;

关键词：

quantum dots; membrane nanotubes; intercellular transportation; single particle tracking; molecular motor; TUG-OF-WAR; LIVING CELLS; IN-VIVO; CYTOPLASMIC DYNEIN; DELIVERY; KINESIN; MECHANISM; DIFFUSION; DYNAMICS; TRACKING;

D O I：

10.1021/nn1002198

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we reported that the quantum dot (QD) nanoparticles could be actively transported in the membrane nanotubes between cardiac myocytes. Single particle imaging and tracking of QDs revealed that most QDs moved in a bidirectional mode along the membrane nanotubes with a mean velocity of 1.23 mu m/s. The results suggested that QDs moving in the nanotubes were coordinately motivated by molecular motors. It provides new information for the study of intercellular transportation of nanoparticles.

引用

页码：3015 / 3022

页数：8

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