Role of imiquimod in skin cancer treatment

被引:38
作者
Urosevic, M [1 ]
Dummer, R [1 ]
机构
[1] Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland
关键词
D O I
10.2165/00128071-200405060-00010
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Cancer of the skin is by far the most common form of all cancers. Given the increasing incidence of skin cancer worldwide, it seems feasible to reconsider the treatment options available for dealing with this growing problem. Despite the lower costs associated with classical methods such as surgery and radiotherapy, immune response modifiers such as imiquimod appear to be good candidates for the future given their good cosmetic effects, the possibility of treating large areas, and the simpleness of patient-applied treatment with a cream formulation. This article reviews current literature on the use of imiquimod in the treatment of nonmelanoma and melanoma skin cancer.
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收藏
页码:453 / 458
页数:6
相关论文
共 47 条
[1]   Imiquimod: a novel treatment for lentigo maligna [J].
Ahmed, I ;
Berth-Jones, J .
BRITISH JOURNAL OF DERMATOLOGY, 2000, 143 (04) :843-845
[2]   Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream [J].
Beutner, KR ;
Geisse, JK ;
Helman, D ;
Fox, TL ;
Ginkel, A ;
Owens, ML .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 41 (06) :1002-1007
[3]   Imiquimod, a topical immune response modifier, in the treatment of cutaneous metastases of malignant melanoma [J].
Bong, AB ;
Bonnekoh, B ;
Franke, I ;
Schön, MP ;
Ulrich, J ;
Gollnick, H .
DERMATOLOGY, 2002, 205 (02) :135-138
[4]  
Born AK, 2002, J INVEST DERMATOL, V119, P758
[5]   Topical imiquimod 5% cream in the treatment of Bowen's disease of the penis [J].
Cook-Bolden, F ;
Weinberg, JM .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2002, 46 (01) :146-147
[6]   The epidemiology of skin cancer [J].
Diepgen, TL ;
Mahler, V .
BRITISH JOURNAL OF DERMATOLOGY, 2002, 146 :1-6
[7]   Imiquimod induces complete clearance of a PUVA-resistant plaque in mycosis fungoides [J].
Dummer, R ;
Urosevic, M ;
Kempf, W ;
Kazakov, D ;
Burg, G .
DERMATOLOGY, 2003, 207 (01) :116-118
[8]   Sezary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (Interferon-gamma receptor beta-chain) [J].
Dummer, R ;
Heald, PW ;
Nestle, FO ;
Ludwig, E ;
Laine, E ;
Hemmi, S ;
Burg, G .
BLOOD, 1996, 88 (04) :1383-1389
[9]   Pathogenesis of cutaneous lymphomas [J].
Dummer, R ;
Willers, J ;
Kamarashev, J ;
Urosevic, M ;
Döbbeling, U ;
Burg, G .
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 2000, 19 (02) :78-86
[10]  
Geisse JK, 2000, DERMATOL SURG, V26, P578