Nanoformulated water-soluble paclitaxel to enhance drug efficacy and reduce hemolysis side effect

被引：14

作者：

Gu, Weiting ^{[1
]}

Chen, Jie ^{[2
]}

Patra, Prabir ^{[3
]}

Yang, Xiaoyan ^{[2
]}

Gu, Quanrong ^{[2
]}

Wei, Lingxuan ^{[1
]}

Acker, Jason P. ^{[4
,5
]}

Kong, Beihua ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Jinan, Peoples R China

[2] Univ Alberta, Dept Biomed Engn, Edmonton, AB, Canada

[3] Univ Bridgeport, Dept Biomed Engn, Bridgeport, CT 06601 USA

[4] Canadian Blood Serv, Ctr Innovat, Edmonton, AB, Canada

[5] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2017年 / 32卷 / 01期

关键词：

Paclitaxel; nanoformulation; pluronic copolymer; self-assembled micelles; water-solubility; tumor suppression and hemolysis; CANCER-THERAPY; MULTIDRUG-RESISTANCE; LIPID NANOCAPSULES; POLYMERIC MICELLES; CREMOPHOR-EL; IN-VITRO; FORMULATION; DELIVERY; CELLS; NANOTECHNOLOGY;

D O I：

10.1177/0885328217708458

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Surgery, chemotherapy, and radiotherapy are the three top cancer treatment modalities. Paclitaxel (PTX) is one of the most widely used chemotherapy drugs. However, its clinical applications have been significantly limited due to: (i) serious hemolysis effect of currently available commercial paclitaxel formulations and (ii) its water insolubility. An easy way to deliver paclitaxel by a new nanocarrier system using pluronic copolymers of P123/F68 and Sorbitan monopalmitate (Span 40) was reported in our previous research article. The characterization of the formulation and analysis of drug release and cellular uptake were also presented. In this article, we reported discoveries of our follow-up invivo antitumor and invitro hemolytic study discoveries. The experimental results showed that the nanoformulated PTX achieved much better tumor suppression performance while reducing hemolysis side effects. This newly formulated drug can significantly improve patient outcomes in cancer chemotherapy.

引用

页码：66 / 73

页数：8

共 41 条

[1] A quality monitoring program for red blood cell components: in vitro quality indicators before and after implementation of semiautomated processing [J].