The consequence of PRELP overexpression on skin

被引：13

作者：

Grover, J.

Lee, E. R.

Mounkes, L. C.

Stewart, C. L.

Roughley, P. J.

机构：

[1] Shriners Hosp Children, Genet Unit, Montreal, PQ H3G 1A6, Canada

[2] McGill Univ, Dept Surg, Montreal, PQ H3A 2T5, Canada

[3] Shriners Hosp Children, Electron Microscopy Unit, Montreal, PQ, Canada

[4] Natl Canc Inst, Canc & Dev Biol lab, Frederick, MD USA

来源：

MATRIX BIOLOGY | 2007年 / 26卷 / 02期

基金：

加拿大健康研究院;

关键词：

PRELP; leucine-rich repeat protein; skin; transgenic mouse;

D O I：

10.1016/j.matbio.2006.10.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PRELP is a member of the small leucine-rich repeat proteoglycan family that is abundantly expressed in many cartilages compared to other connective tissues. To study the consequence of PRELP overexpression in tissues where it is normally expressed at low abundance, transgenic mice were generated in which the human PRELP transgene was placed under control of the CMV promoter. A connective tissue phenotype was observed in the skin, where the organization of collagen fibrils in the dermis was perturbed and the thickness of the hypodermal fat layer was diminished. (c) 2006 Elsevier B.V./Intemational Society of Matrix Biology. All rights reserved.

引用

页码：140 / 143

页数：4

共 14 条

[1] Mice deficient in small leucine-rich proteoglycans:: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases [J].