Function of CCL5 in maternal-fetal interface of pig during early pregnancy

被引：6

作者：

Bae, Hyocheol ^{[1
,2
]}

Lee, Jin-Young ^{[3
]}

Song, Gwonhwa ^{[1
,2
]}

Lim, Whasun ^{[4
]}

机构：

[1] Korea Univ, Coll Life Sci & Biotechnol, Inst Anim Mol Biotechnol, Seoul 02841, South Korea

[2] Korea Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 02841, South Korea

[3] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA

[4] Kookmin Univ, Dept Food & Nutr, Seoul 02707, South Korea

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2020年 / 103卷

基金：

新加坡国家研究基金会;

关键词：

CCL5; CCR3; Endometrium; Pig; Uterine epithelial cell; Development; TOLL-LIKE RECEPTORS; DECIDUAL CELLS; CHEMOKINE; INFLAMMATION; INHIBITOR; STRESS; TROPHOBLAST; MECHANISMS; EXPRESSION; GROWTH;

D O I：

10.1016/j.dci.2019.103503

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Chemokines refer to chemoattractant cytokines, which have crucial functions in inflammation and immune responses in multiple cellular processes. In the present study, we described the potential role of porcine CCL5 in embryo implantation and fetal-maternal environment during early pregnancy. We first carried out phylogenetic analysis of porcine CCL5, and analyzed the cell specific localization of CCL5 and its receptor CCR3 in a kinetic approach within porcine estrous cycles and early gestation stage. In addition, CCL5 stimulated porcine uterine luminal epithelial (pLE) and porcine trophectoderm (pTr) cell proliferations, and cell cycle progressions via AKT and MAPK intracellular signaling tractions. Furthermore, CCL5 attenuated tunicamycin-induced endoplasmic reticulum (ER) stress signaling, and lipopolysaccharides-triggered inflammatory responses in pLE and pTr cells. Taken together, our study showed that CCL5 is involved in the placental development or promotes the placental development.

引用

页数：10

共 49 条

[1] Macrophages and apoptotic cell clearance during pregnancy [J].

Abrahams, VM ;

Kim, YM ;

Straszewski, SL ;

Romero, R ;

Mor, G .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2004, 51 (04) :275-282

[2] Mitigation of ER-stress and inflammation by chemokine (C-C motif) ligand 21 during early pregnancy [J].

Bae, Hyocheol ;

Lim, Whasun ;

Bazer, Fuller W. ;

Whang, Kwang-Youn ;

Song, Gwonhwa .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2019, 94 :73-84

[3] Pig blastocyst-uterine interactions [J].

Bazer, Fuller W. ;

Johnson, Gregory A. .

DIFFERENTIATION, 2014, 87 (1-2) :52-65

[4] SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase [J].

Bennett, BL ;

Sasaki, DT ;

Murray, BW ;

O'Leary, EC ;

Sakata, ST ;

Xu, WM ;

Leisten, JC ;

Motiwala, A ;

Pierce, S ;

Satoh, Y ;

Bhagwat, SS ;

Manning, AM ;

Anderson, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13681-13686

[5] Peripheral Monocyte Expression of the Chemokine Receptors CCR2, CCR5 and CXCR3 is Altered at Parturition in Healthy Women and in Women with Systemic Lupus Erythematosus [J].

Bjorkander, S. ;

Heidari-Hamedani, G. ;

Bremme, K. ;

Gunnarsson, I. ;

Holmlund, U. .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2013, 77 (03) :200-212

[6] Chemokine decoy receptors: New players in reproductive immunology [J].

Borroni, Elena Monica ;

Bonecchi, Raffaella ;

Buracchi, Chiara ;

Savino, Benedetta ;

Mantovani, Alberto ;

Locati, Massimo .

IMMUNOLOGICAL INVESTIGATIONS, 2008, 37 (5-6) :483-497

[7] Mechanisms of implantation: strategies for successful pregnancy [J].

Cha, Jeeyeon ;

Sun, Xiaofei ;

Dey, Sudhansu K. .

NATURE MEDICINE, 2012, 18 (12) :1754-1767

[8] The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs) [J].

Clerk, A ;

Sugden, PH .

FEBS LETTERS, 1998, 426 (01) :93-96

[9] IDENTIFICATION OF RANTES, MIP-1-ALPHA, AND MIP-1-BETA AS THE MAJOR HIV-SUPPRESSIVE FACTORS PRODUCED BY CD8(+) T-CELLS [J].

COCCHI, F ;

DEVICO, AL ;

GARZINODEMO, A ;

ARYA, SK ;

GALLO, RC ;

LUSSO, P .

SCIENCE, 1995, 270 (5243) :1811-1815

[10] The integrative roles of chemokines at the maternal-fetal interface in early pregnancy [J].

Du, Mei-Rong ;

Wang, Song-Cun ;

Li, Da-Jin .

CELLULAR & MOLECULAR IMMUNOLOGY, 2014, 11 (05) :438-448

← 1 2 3 4 5 →