Pharmacokinetics of telithromycin in plasma and soft tissues after single-dose administration to healthy volunteers

被引:21
作者
Gattringer, R
Urbauer, E
Traunmüller, F
Zeitlinger, M
Dehghanyar, P
Zeleny, P
Graninger, W
Müller, M
Joukhadar, C
机构
[1] Med Univ Vienna, Dept Clin Pharmacol, Div Clin Pharmacokinet, A-1090 Vienna, Austria
[2] Med Univ Vienna, Dept Internal Med 1, Div Infect Dis & Chemotherapy, A-1090 Vienna, Austria
[3] Med Univ Vienna, Inst Pharmacol, A-1090 Vienna, Austria
关键词
D O I
10.1128/AAC.48.12.4650-4653.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
By use of microdialysis we assessed the concentrations of telithromycin in muscle and adipose tissue to test its ability to penetrate soft tissues. The ratios of the area under the concentration-versus-time curve from 0 to 24 h to the MIC indicated that free concentrations of telithromycin in tissue and plasma might be effective against Streptococcus pyogenes but not against staphylococci and human and animal bite pathogens.
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页码:4650 / 4653
页数:4
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