Checkpoint for gut microbes after birth

被引：4

作者：

Macpherson, Andrew J. ^{[1
,2
]}

Ganal-Vonarburg, Stephanie C. ^{[1
,2
]}

机构：

[1] Bern Univ Hosp, Univ Clin Visceral Surg & Med, CH-3008 Bern, Switzerland

[2] Univ Bern, Dept BioMed Res, CH-3008 Bern, Switzerland

来源：

NATURE | 2018年 / 560卷 / 7719期

基金：

欧盟地平线“2020”;

关键词：

EARLY-LIFE; INTESTINAL MICROBIOTA; METABOLIC SYNDROME; IMMUNE-SYSTEM; RECEPTOR; 5; MICE; SHAPES; INFLAMMATION; ANTIBODIES;

D O I：

10.1038/d41586-018-05861-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The route to the establishment of a beneficial microbial community in the gut after birth is not fully understood. It now emerges that a gut-cell protein in newborn mice shapes the long-term composition of this community. [Figure not available: see fulltext.]. © 2018, Nature.

引用

页码：436 / 438

页数：3

共 13 条

[1] Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice [J].

Carvalho, Frederic A. ;

Koren, Omry ;

Goodrich, Julia K. ;

Johansson, Malin E. V. ;

Nalbantoglu, Ilke ;

Aitken, Jesse D. ;

Su, Yueju ;

Chassaing, Benoit ;

Walters, William A. ;

Gonzalez, Antonio ;

Clemente, Jose C. ;

Cullender, Tyler C. ;

Barnich, Nicolas ;

Darfeuille-Michaud, Arlette ;

Vijay-Kumar, Matam ;

Knight, Rob ;

Ley, Ruth E. ;

Gewirtz, Andrew T. .

CELL HOST & MICROBE, 2012, 12 (02) :139-152

[2] Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice [J].

Chassaing, Benoit ;

Ley, Ruth E. ;

Gewirtz, Andrew T. .

GASTROENTEROLOGY, 2014, 147 (06) :1363-+

[3] The maternal microbiota drives early postnatal innate immune development [J].

de Agueero, Mercedes Gomez ;

Ganal-Vonarburg, Stephanie C. ;

Fuhrer, Tobias ;

Rupp, Sandra ;

Uchimura, Yasuhiro ;

Li, Hai ;

Steinert, Anna ;

Heikenwalder, Mathias ;

Hapfelmeier, Siegfried ;

Sauer, Uwe ;

McCoy, Kathy D. ;

Macpherson, Andrew J. .

SCIENCE, 2016, 351 (6279) :1296-1301

[4] Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns [J].

Dominguez-Bello, Maria G. ;

Costello, Elizabeth K. ;

Contreras, Monica ;

Magris, Magda ;

Hidalgo, Glida ;

Fierer, Noah ;

Knight, Rob .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (26) :11971-11975

[5] Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition [J].

Fulde, Marcus ;

Sommer, Felix ;

Chassaing, Benoit ;

van Vorst, Kira ;

Dupont, Aline ;

Hensel, Michael ;

Basic, Marijana ;

Klopfleisch, Robert ;

Rosenstiel, Philip ;

Bleich, Andre ;

Baeckhed, Fredrik ;

Gewirtz, Andrew T. ;

Hornef, Mathias W. .

NATURE, 2018, 560 (7719) :489-+

[6] How colonization by microbiota in early life shapes the immune system [J].

Gensollen, Thomas ;

Iyer, Shankar S. ;

Kasper, Dennis L. ;

Blumberg, Richard S. .

SCIENCE, 2016, 352 (6285) :539-544

[7] Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life [J].

Koch, Meghan A. ;

Reiner, Gabrielle L. ;

Lugo, Kyler A. ;

Kreuk, Lieselotte S. M. ;

Stanbery, Alison G. ;

Ansaldo, Eduard ;

Seher, Thaddeus D. ;

Ludington, William B. ;

Barton, Gregory M. .

CELL, 2016, 165 (04) :827-841

[8] How nutrition and the maternal microbiota shape the neonatal immune system [J].

Macpherson, Andrew J. ;

de Agueero, Mercedes Gomez ;

Ganal-Vonarburg, Stephanie C. .

NATURE REVIEWS IMMUNOLOGY, 2017, 17 (08) :508-517

[9] Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function [J].

Olszak, Torsten ;

An, Dingding ;

Zeissig, Sebastian ;

Vera, Miguel Pinilla ;

Richter, Julia ;

Franke, Andre ;

Glickman, Jonathan N. ;

Siebert, Reiner ;

Baron, Rebecca M. ;

Kasper, Dennis L. ;

Blumberg, Richard S. .

SCIENCE, 2012, 336 (6080) :489-493

[10] Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression [J].

Rogier, Eric W. ;

Frantz, Aubrey L. ;

Bruno, Maria E. C. ;

Wedlund, Leia ;

Cohen, Donald A. ;

Stromberg, Arnold J. ;

Kaetzel, Charlotte S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (08) :3074-3079

← 1 2 →