Possible role of retrotrapezoid nucleus and parapyramidal area in the respiratory response to anoxia:: an in vitro study in neonatal rat

被引:20
作者
Bodineau, L [1 ]
Cayetanot, F [1 ]
Frugière, A [1 ]
机构
[1] Fac Med, Lab Neurophysiol Dev, Dept Environm Tox Perinatal & Adaptat Physiol Com, F-80036 Amiens 01, France
关键词
anoxia; brainstem-spinal cord; in vitro; neonatal rat; parapyramidal area; respiratory rhythm; retrotrapezoid nucleus;
D O I
10.1016/S0304-3940(00)01590-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The brainstem-spinal cord preparation from neonatal rat has been used in several reports to evaluate the central effect of low oxygen level on the respiratory network. We demonstrate that bilateral lesion of retrotrapezoid nucleus and parapyramidal area unmasks an early reinforcement of the respiratory output in response to anoxia. This suggests that neurons in both areas might trigger or relay a central depressive influence of hypoxia on the respiratory network. (C) 2000 Published by Elsevier Science ireland Ltd.
引用
收藏
页码:67 / 69
页数:3
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