Bacterial microcompartments and the modular construction of microbial metabolism

被引：133

作者：

Kerfeld, Cheryl A. ^{[1
,2
,3
,4
]}

Erbilgin, Onur ^{[2
]}

机构：

[1] Michigan State Univ, DOE Plant Res Lab, E Lansing, MI 48824 USA

[2] Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA

[4] Berkeley Synthet Biol Inst, Berkeley, CA USA

来源：

TRENDS IN MICROBIOLOGY | 2015年 / 23卷 / 01期

基金：

美国国家科学基金会;

关键词：

bacterial microcompartments; carboxysomes; metabolosomes; synthetic biology; bacterial organelles; B-12-DEPENDENT 1,2-PROPANEDIOL DEGRADATION; SHELL PROTEIN; SALMONELLA-ENTERICA; CARBOXYSOME SHELL; INCREASE PHOTOSYNTHESIS; LACTOBACILLUS-REUTERI; STRUCTURAL INSIGHTS; CRYSTAL-STRUCTURES; DIOL DEHYDRATASE; ORGANELLE;

D O I：

10.1016/j.tim.2014.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial microcompartments (BMCs) are protein-bound organelles predicted to be present across 23 bacterial phyla. BMCs facilitate carbon fixation as well as the aerobic and anaerobic catabolism of a variety of organic compounds. These functions have been linked to ecological nutrient cycling, symbiosis, pathogenesis, and cardiovascular disease. Within bacterial cells, BMCs are metabolic modules that can be further dissociated into their constituent structural and functional protein domains. Viewing BMCs as genetic, structural, functional, and evolutionary modules provides a framework for understanding both BMC-mediated metabolism and for adapting their architectures for applications in synthetic biology.

引用

页码：22 / 34

页数：13

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