Prospective Therapeutic Applications of Platelet Extracellular Vesicles

被引：93

作者：

Johnson, Jancy ^{[1
,2
]}

Wu, Yu-Wen ^{[3
]}

Blyth, Chantelle ^{[1
]}

Lichtfuss, Gregor ^{[1
,2
]}

Goubran, Hadi ^{[4
,5
]}

Burnouf, Thierry ^{[3
,6
,7
]}

机构：

[1] Exopharm Ltd, Level 17,31 Queen St, Melbourne, Vic 3000, Australia

[2] Univ Melbourne, Dept Pharmacol & Therapeut, Parkville, Vic 3010, Australia

[3] Taipei Med Univ, Coll Biomed Engn, Grad Inst Biomed Mat & Tissue Engn, Taipei, Taiwan

[4] Univ Saskatchewan, Saskatoon Canc Ctr, Saskatoon, SK, Canada

[5] Univ Saskatchewan, Coll Med, Saskatoon, SK, Canada

[6] Taipei Med Univ, Coll Biomed Engn, Int PhD Program Biomed Engn, Taipei, Taiwan

[7] Taipei Med Univ, Coll Med, Int PhD Program Cell Therapy & Regenerat Med, Taipei, Taiwan

来源：

TRENDS IN BIOTECHNOLOGY | 2021年 / 39卷 / 06期

关键词：

MICROPARTICLES INDUCE ANGIOGENESIS; DRUG-DELIVERY; EXOSOMES; ACTIVATION; MEMBRANE; CANCER; NANOFILTRATION; INFLAMMATION; AGGREGATION; TRANSFUSION;

D O I：

10.1016/j.tibtech.2020.10.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles. Researchers in academic fields and the cell therapy and biotechnology industries have a great interest in the translational potential of EVs (see Glossary), which, as described by the International Society of Extracellular Vesicles (ISEV) is 'a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, and apoptotic bodies', among others [1]. These heterogeneous cell-derived vesicles are 'delimited by a

引用

页码：598 / 612

页数：15

共 92 条

[21] Nanofiltration to remove microparticles and decrease the thrombogenicity of plasma: in vitro feasibility assessment [J].