Increase of neuronal nitric oxide synthase in rat skeletal muscle during ageing

被引：31
作者：
Capanni, C
Squarzoni, S
Petrini, S
Villanova, M
Muscari, C
Maraldi, NM
Guarnieri, C
Caldarera, CM
机构：
[1] Univ Bologna, Dipartimento Biochim G Moruzzi, I-40126 Bologna, Italy
[2] IOR, CNR, Ist Citomorfol, Bologna, Italy
[3] IOR, Lab Patol Neuromuscolare, Bologna, Italy
[4] Univ Siena, Ist Sci Neurol, I-53100 Siena, Italy
[5] IOR, Lab Biol Cellulare & Microscopia Elettron, Bologna, Italy
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 245卷 / 01期
关键词：
D O I：
10.1006/bbrc.1998.8404
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide synthases (NOS) are different widely expressed enzymes which produce the molecular messenger nitric oxide. The neuronal isoform of NOS (nNOS) is involved in several processes of the cell metabolism, most of which are, at present, not fully understood (neurotransmission, smooth muscle motility, myoblast and myocyte biology and others). In skeletal muscle nNOS is present mainly at the plasmalemma, where it is attached to the dystrophin-related proteins; in fact, in pathologies involving dystrophin, nNOS is altered as well. We report that in aged rats the nNOS amount in skeletal muscle in creases both in the soluble and microsomal fractions and that an additional intracytoplasmic localisation appears. (C) 1998 Academic Press.
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页码：216 / 219
页数：4
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