The three-dimensional cancer genome

被引：42

作者：

Corces, M. Ryan ^{[1
]}

Corces, Victor G. ^{[2
]}

机构：

[1] Stanford Univ, Sch Med, Ctr Personal Dynam Regulomes, Stanford, CA 94305 USA

[2] Emory Univ, Dept Biol, 1510 Clifton Rd NE, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2016年 / 36卷

基金：

美国国家卫生研究院;

关键词：

CHROMATIN ARCHITECTURE; TRANSCRIPTION FACTOR; GENE-EXPRESSION; BLADDER-CANCER; MUTATIONAL PROCESSES; SEQUENCING REVEALS; COHESIN COMPLEX; WHOLE-GENOME; HUMAN-CELLS; CTCF;

D O I：

10.1016/j.gde.2016.01.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past decade of cancer research has ushered in a comprehensive understanding of the way that the sequence of the genome can be co-opted during the process of tumorigenesis. However, only recently has the epigenome, and in particular the three-dimensional topology of chromatin, been implicated in cancer progression. Here we review recent findings of how the cancer genome is regulated and dysregulated to effect changes in 3D genome topology. We discuss the impact of the spatial organization of the genome on the frequency of tumorigenic chromosomal translocations and the effects of disruption of the proteins responsible for the establishment of chromatin loops. Alteration of the three-dimensional cancer genome is a rapidly emerging hallmark of multiple cancer subtypes.

引用

页码：1 / 7

页数：7

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