Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review

被引：40

作者：

Aminimoghadamfarouj, Noushin ^{[1
]}

Nematollahi, Alireza ^{[1
]}

机构：

[1] Univ Sydney, Fac Pharm A15, Sydney, NSW 2006, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 06期

关键词：

propolis; diterpenes; anticancer; antibacterial; Brazilian propolis; Mediterranean propolis; European propolis; BRAZILIAN RED PROPOLIS; ANTIBACTERIAL ACTIVITY; CHEMICAL-COMPOSITION; ANTIMICROBIAL ACTIVITY; TOTAROL DERIVATIVES; ANTIINFLAMMATORY ACTIVITY; BIOLOGICAL-ACTIVITIES; PHENOLIC DITERPENE; BIOACTIVE MOLECULE; ANTIVIRAL ACTIVITY;

D O I：

10.3390/ijms18061290

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Propolis is one of the complex, but valuable, bio-sources for discovering therapeutic compounds. Diterpenes are organic compounds composed of four isoprene units and are known for their biological and pharmacological characteristics, such as antibacterial, anticancer, and anti-inflammatory activities. Recently, advancements have been made in the development of antibacterial and anticancer leads from propolis-isolated diterpenes, and scrutiny of these compounds is being pursued. Thus, this review covers the progress in this arena, with a focus on the chemistry and biological activities of propolis diterpenes. It is anticipated that important information, in a comprehensive and concise manner, will be delivered here for better understanding of natural product drug discovery research.

引用

页数：14

共 138 条

[1] Prenylated cinnamate and stilbenes from Kangaroo Island propolis and their antioxidant activity [J].

Abu-Mellal, Abdallah ;

Koolaji, Nooshin ;

Duke, Rujee K. ;

Tran, Van H. ;

Duke, Colin C. .

PHYTOCHEMISTRY, 2012, 77 :251-259

[2] Antimicrobial activity of the diterpenes flexibilide and sinulariolide derived from Sinularia flexibilis Quoy and Gaimard 1833 (Coelenterata: Alcyonacea, Octocorallia) [J].

Aceret, TL ;

Coll, JC ;

Uchio, Y ;

Sammarco, PW .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1998, 120 (01) :121-126

[3] Isolation of diterpenes and flavonoids from a new type of propolis from Saudi Arabia [J].

Almutairi, Sultan ;

Edrada-Ebel, RuAngelie ;

Fearnley, James ;

Igoli, John O. ;

Alotaibi, Waqas ;

Clements, Carol J. ;

Gray, Alexander I. ;

Watson, David G. .

PHYTOCHEMISTRY LETTERS, 2014, 10 :160-163

[4] New anti-trypanosomal active prenylated compounds from African propolis [J].

Almutairi, Sultan ;

Eapen, Ben ;

Chundi, Sai Maneesha ;

Akhalil, Adnan ;

Siheri, Weam ;

Clements, Carol ;

Fearnley, James ;

Watson, David G. ;

Edrada-Ebel, RuAngelie .

PHYTOCHEMISTRY LETTERS, 2014, 10 :35-39

[5] Annonaceae: bio-resource for tomorrow's drug discovery [J].

Aminimoghadamfarouj, Noushin ;

Nematollahi, Alireza ;

Wiart, Christophe .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2011, 13 (05) :465-476

[6] INVITRO ANTIVIRAL ACTIVITY OF PROPOLIS [J].

AMOROS, M ;

SAUVAGER, F ;

GIRRE, L ;

CORMIER, M .

APIDOLOGIE, 1992, 23 (03) :231-240

[7] Pharmacognostic and acute toxicological evaluation of Scaptotrigona aff. postica propolis extract in pre-clinical assays [J].

Araujo, M. J. A. M. ;

Mattar, N. S. ;

Reis, A. S. ;

Serra, I. C. P. B. ;

Fialho, E. M. S. ;

Assuncao, A. K. M. ;

Dutra, R. P. ;

Nogueira, A. M. C. ;

Liberio, S. A. ;

Guerra, R. N. M. ;

Lopes, A. S. ;

Ribeiro, M. N. S. ;

Nascimento, F. R. F. .

NATURAL PRODUCT RESEARCH, 2011, 25 (11) :1037-1046

[8]

Bankova V, 1996, Z NATURFORSCH C, V51, P277

[9] Chemical diversity of propolis and the problem of standardization [J].

Bankova, V .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 100 (1-2) :114-117

[10] Chemical composition of Propolis Extract ACF® and activity against herpes simplex virus [J].

Bankova, V. ;

Galabov, A. S. ;

Antonova, D. ;

Vilhelmova, N. ;

Di Perri, B. .

PHYTOMEDICINE, 2014, 21 (11) :1432-1438

← 1 2 3 4 5 6 7 8 9 10 →