Translating Animal Model Research: Does It Matter That Our Rodents Are Cold?

被引：138

作者：

Maloney, Shane K. ^{[1
,2
]}

Fuller, Andrea ^{[2
]}

Mitchell, Duncan ^{[1
,2
]}

Gordon, Christopher ^{[3
]}

Overton, J. Michael ^{[4
]}

机构：

[1] Univ Western Australia, Sch Anat Physiol & Human Biol, Crawley, WA, Australia

[2] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Brain Funct Res Grp, Parktown, South Africa

[3] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA

[4] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA

来源：

PHYSIOLOGY | 2014年 / 29卷 / 06期

关键词：

BROWN ADIPOSE-TISSUE; NONSHIVERING THERMOGENESIS; CALORIC RESTRICTION; AMBIENT-TEMPERATURE; TRANSGENIC MICE; LABORATORY MICE; MOUSE; BODY; THERMONEUTRALITY; PHYSIOLOGY;

D O I：

10.1152/physiol.00029.2014

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumor-prone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality.

引用

页码：413 / 420

页数：8

共 66 条

[1]

[Anonymous], 2011, Committee for the update of the guide for the care and use of laboratory animals, guide for the care and use of laboratory animals

[2] A general basis for quarter-power scaling in animals [J].

Banavar, Jayanth R. ;

Moses, Melanie E. ;

Brown, James H. ;

Damuth, John ;

Rinaldo, Andrea ;

Sibly, Richard M. ;

Maritan, Amos .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (36) :15816-15820

[3]

Bartholomew G.A., 1977, Animal Physiology, P364

[4]

Bartke A, 2012, FRONT GENET, V288, P1

[5] Use of animals in experimental research: an ethical dilemma? [J].

Baumans, V .

GENE THERAPY, 2004, 11 (Suppl 1) :S64-S66

[6] BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality [J].

Boon, Mariette R. ;

van den Berg, Sjoerd A. A. ;

Wang, Yanan ;

van den Bossche, Jan ;

Karkampouna, Sofia ;

Bauwens, Matthias ;

De Saint-Hubert, Marijke ;

van der Horst, Geertje ;

Vukicevic, Slobodan ;

de Winther, Menno P. J. ;

Havekes, Louis M. ;

Jukema, J. Wouter ;

Tamsma, Jouke T. ;

van der Pluijm, Gabri ;

van Dijk, Ko Willems ;

Rensen, Patrick C. N. .

PLOS ONE, 2013, 8 (09)

[7] The mammalian gene function resource: the international knockout mouse consortium [J].

Bradley, Allan ;

Anastassiadis, Konstantinos ;

Ayadi, Abdelkader ;

Battey, James F. ;

Bell, Cindy ;

Birling, Marie-Christine ;

Bottomley, Joanna ;

Brown, Steve D. ;

Buerger, Antje ;

Bult, Carol J. ;

Bushell, Wendy ;

Collins, Francis S. ;

Desaintes, Christian ;

Doe, Brendan ;

Economides, Aris ;

Eppig, Janan T. ;

Finnell, Richard H. ;

Fletcher, Colin ;

Fray, Martin ;

Frendewey, David ;

Friedel, Roland H. ;

Grosveld, Frank G. ;

Hansen, Jens ;

Herault, Yann ;

Hicks, Geoffrey ;

Hoerlein, Andreas ;

Houghton, Richard ;

de Angelis, Martin Hrabe ;

Huylebroeck, Danny ;

Iyer, Vivek ;

de Jong, Pieter J. ;

Kadin, James A. ;

Kaloff, Cornelia ;

Kennedy, Karen ;

Koutsourakis, Manousos ;

Lloyd, K. C. Kent ;

Marschall, Susan ;

Mason, Jeremy ;

McKerlie, Colin ;

McLeod, Michael P. ;

von Melchner, Harald ;

Moore, Mark ;

Mujica, Alejandro O. ;

Nagy, Andras ;

Nefedov, Mikhail ;

Nutter, Lauryl M. ;

Pavlovic, Guillaume ;

Peterson, Jane L. ;

Pollock, Jonathan ;

Ramirez-Solis, Ramiro .

MAMMALIAN GENOME, 2012, 23 (9-10) :580-586

[8] GH and IGF1: Roles in Energy Metabolism of Long-Living GH Mutant Mice [J].

Brown-Borg, Holly M. ;

Bartke, Andrzej .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2012, 67 (06) :652-660

[9] Dwarf mice and the ageing process [J].

BrownBorg, HM ;

Borg, KE ;

Meliska, CJ ;

Bartke, A .

NATURE, 1996, 384 (6604) :33-33

[10] A warmer ambient temperature increases the passage of interleukin-1β into the brains of old rats [J].

Buchanan, Jessica B. ;

Peloso, Elizabeth ;

Satinoff, Evelyn .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2008, 295 (01) :R361-R368

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