Translating Animal Model Research: Does It Matter That Our Rodents Are Cold?

被引：134
作者：
Maloney, Shane K. [1 ,2 ]
Fuller, Andrea [2 ]
Mitchell, Duncan [1 ,2 ]
Gordon, Christopher [3 ]
Overton, J. Michael [4 ]
机构：
[1] Univ Western Australia, Sch Anat Physiol & Human Biol, Crawley, WA, Australia
[2] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Brain Funct Res Grp, Parktown, South Africa
[3] US EPA, Tox Assessment Div, Res Triangle Pk, NC 27711 USA
[4] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
来源：
PHYSIOLOGY | 2014年 / 29卷 / 06期
关键词：
BROWN ADIPOSE-TISSUE; NONSHIVERING THERMOGENESIS; CALORIC RESTRICTION; AMBIENT-TEMPERATURE; TRANSGENIC MICE; LABORATORY MICE; MOUSE; BODY; THERMONEUTRALITY; PHYSIOLOGY;
D O I：
10.1152/physiol.00029.2014
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumor-prone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality.
引用
收藏
页码：413 / 420
页数：8
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