The Research Advances in The Field of Lipidomics

被引：8

作者：

Cai Tan-Xi ^{[1
]}

Liu Ping-Sheng ^{[1
]}

Yang Fu-Quan ^{[1
]}

Yang Fu-Yu ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2010年 / 37卷 / 02期

关键词：

lipidomics; mass spectrometry; metabolic diseases; OXIDATIVE LIPIDOMICS; MASS-SPECTROMETRY; CRUDE EXTRACTS; SPHINGOSINE; LIPIDS; REVEALS; PLASMA;

D O I：

10.3724/SP.J.1206.2009.00479

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipidomics, a newly emerging field, is systems-level analysis and characterization of lipids and their interacting moieties. Lipids play essential roles in several cellular processes, such as membrane transport, sorting and cell signaling. Previous studies have revealed possible links between deregulated lipid metabolism and a wide variety of diseases, including diabetes, obesity, cancer, as well as neurodegenerative diseases. All these make the field of lipidomics a promising area of biological research. In fact, lipidomic research has been applied to many fields, such as drug development, molecular biology, molecular pathology, functional genomics, nutriology, environmental science, and so on. The progress in the field of lipidomics, including the present situation and the future application, was summarized.

引用

页码：121 / 128

页数：8

共 36 条

[1] Eicosanomics: targeted lipidomics of eicosanoids in biological systems [J].

Balazy, M .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2004, 73 (3-4) :173-180

[2] Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic [J].

Bartz, Rene ;

Li, Wen-Hong ;

Venables, Barney ;

Zehmer, John K. ;

Roth, Mary R. ;

Welti, Ruth ;

Anderson, Richard G. W. ;

Liu, Pingsheng ;

Chapman, Kent D. .

JOURNAL OF LIPID RESEARCH, 2007, 48 (04) :837-847

[3]

BASLER JW, 2004, J UROLOGY, V171, P59

[4] The role of sphingosine and ceramide kinases in inflammatory responses [J].

Baumruker, T ;

Bornancin, F ;

Billich, A .

IMMUNOLOGY LETTERS, 2005, 96 (02) :175-185

[5] Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology [J].

Brinkmann, Volker .

PHARMACOLOGY & THERAPEUTICS, 2007, 115 (01) :84-105

[6] The HIV lipidome:: A raft with an unusual composition [J].

Brügger, B ;

Glass, B ;

Haberkant, P ;

Leibrecht, I ;

Wieland, FT ;

Kräusslich, HG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :2641-2646

[7]

Cheng H., 2008, Neurobiol Aging

[8] Integrative biological analysis of the APOE*3-Leiden transgenic mouse [J].

Clish, CB ;

Davidov, E ;

Oresic, M ;

Plasterer, TN ;

Lavine, G ;

Londo, T ;

Meys, M ;

Snell, P ;

Stochaj, W ;

Adourian, A ;

Zhang, X ;

Morel, N ;

Neumann, E ;

Verheij, E ;

Vogels, JTWE ;

Havekes, LM ;

Afeyan, N ;

Regnier, F ;

Van Der Greef, J ;

Naylor, S .

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2004, 8 (01) :3-13

[9] Using genomic and lipidomic strategies to investigate sphingolipid function in the yeast heat-stress response [J].

Cowart, LA ;

Hannun, YA .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2005, 33 :1166-1169

[10] Sphingosine in apoptosis signaling [J].

Cuvillier, O .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2002, 1585 (2-3) :153-162

← 1 2 3 4 →