Development of the hypothalamus: conservation, modification and innovation

被引：108

作者：

Xie, Yuanyuan ^{[1
]}

Dorsky, Richard I. ^{[1
]}

机构：

[1] Univ Utah, Dept Neurobiol & Anat, Salt Lake City, UT 84112 USA

来源：

DEVELOPMENT | 2017年 / 144卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Hypothalamus; Wnt; Evolution; Adult neurogenesis; CENTRAL-NERVOUS-SYSTEM; NEURAL STEM-CELLS; ADULT ZEBRAFISH BRAIN; SONIC-HEDGEHOG; SUPRACHIASMATIC NUCLEUS; DEVELOPING FOREBRAIN; HOMEODOMAIN PROTEIN; MICE LACKING; FLOOR-PLATE; NEUROENDOCRINE HYPOTHALAMUS;

D O I：

10.1242/dev.139055

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The hypothalamus, which regulates fundamental aspects of physiological homeostasis and behavior, is a brain region that exhibits highly conserved anatomy across vertebrate species. Its development involves conserved basic mechanisms of induction and patterning, combined with a more plastic process of neuronal fate specification, to produce brain circuits that mediate physiology and behavior according to the needs of each species. Here, we review the factors involved in the induction, patterning and neuronal differentiation of the hypothalamus, highlighting recent evidence that illustrates how changes in Wnt/beta-catenin signaling during development may lead to species-specific form and function of this important brain structure.

引用

收藏

页码：1588 / 1599

页数：12

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