CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia

被引：1

作者：

Xue, Yao ^{[1
]}

Rong, Liucheng ^{[1
]}

Tong, Na ^{[2
]}

Wang, Meilin ^{[2
]}

Zhang, Zhengdong ^{[2
]}

Fang, Yongjun ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Nanjing Childrens Hosp, Dept Hematol & Oncol, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Ctr Canc, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Dept Environm Genom, Nanjing 210029, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 09期

关键词：

CCND1; polymorphism; MTX toxicity; childhood acute lymphoblastic leukemia; CYCLIN D1; METHYLENETETRAHYDROFOLATE REDUCTASE; MOLECULAR-MECHANISMS; GENE; RESISTANCE; CHILDREN; LEUCOVORIN; VARIANTS; DISEASE; CANCER;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CCND1 plays a key role in cell cycle progression and may cause methotrexate (MTX) resistance, as well as its cytotoxicity. CCND1 870A variant allele is associated with altered transcripts of this gene. We hypothesized that this polymorphism may contribute to the elimination rate and hepatotoxicity of MTX in childhood acute lymphoblastic leukemia (ALL). We genotyped the CCND1 G870A polymorphism in 125 childhood ALL patients treated with HDMTX. We found no notable associations between G870A polymorphism and the risk of delayed MTX elimination. However, this polymorphism was significantly associated with an increased risk of MTX hepatotoxicity [adjusted odds ratio (OR) = 4.44, 95% confidence interval (CI) = 1.35-14.63 for AG versus GG and adjusted OR = 6.39, 95% CI = 1.82-22.43 for AA versus GG]. Our results indicated that the CCND1 G870A polymorphism may be involved in the hepatotoxicity of MTX and act as a biological marker.

引用

页码：11594 / 11600

页数：7

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