CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia

被引：1
作者：
Xue, Yao [1 ]
Rong, Liucheng [1 ]
Tong, Na [2 ]
Wang, Meilin [2 ]
Zhang, Zhengdong [2 ]
Fang, Yongjun [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Nanjing Childrens Hosp, Dept Hematol & Oncol, Nanjing 210008, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Ctr Canc, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Dept Environm Genom, Nanjing 210029, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 09期
关键词：
CCND1; polymorphism; MTX toxicity; childhood acute lymphoblastic leukemia; CYCLIN D1; METHYLENETETRAHYDROFOLATE REDUCTASE; MOLECULAR-MECHANISMS; GENE; RESISTANCE; CHILDREN; LEUCOVORIN; VARIANTS; DISEASE; CANCER;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CCND1 plays a key role in cell cycle progression and may cause methotrexate (MTX) resistance, as well as its cytotoxicity. CCND1 870A variant allele is associated with altered transcripts of this gene. We hypothesized that this polymorphism may contribute to the elimination rate and hepatotoxicity of MTX in childhood acute lymphoblastic leukemia (ALL). We genotyped the CCND1 G870A polymorphism in 125 childhood ALL patients treated with HDMTX. We found no notable associations between G870A polymorphism and the risk of delayed MTX elimination. However, this polymorphism was significantly associated with an increased risk of MTX hepatotoxicity [adjusted odds ratio (OR) = 4.44, 95% confidence interval (CI) = 1.35-14.63 for AG versus GG and adjusted OR = 6.39, 95% CI = 1.82-22.43 for AA versus GG]. Our results indicated that the CCND1 G870A polymorphism may be involved in the hepatotoxicity of MTX and act as a biological marker.
引用
收藏
页码：11594 / 11600
页数：7
相关论文
共 50 条
  • [21] Distribution of CCND1 A870G Polymorphism in Patients with Advanced Uterine Cervical Carcinoma
    Warchol, Teresa
    Kruszyna, Lukasz
    Lianeri, Margarita
    Roszak, Andrzej
    Jagodzinski, Pawel P.
    PATHOLOGY & ONCOLOGY RESEARCH, 2011, 17 (01) : 133 - 137
  • [22] Absence of association between cyclin D1 (CCND1) G870A polymorphism and age of onset in hereditary nonpolyposis colorectal cancer
    Krüger, S
    Engel, C
    Bier, A
    Mangold, E
    Pagenstecher, C
    Doeberitz, MV
    Holinski-Feder, E
    Moeslein, G
    Keller, G
    Kunstmann, E
    Friedl, W
    Plaschke, J
    Rüschoff, J
    Schackert, HK
    CANCER LETTERS, 2006, 236 (02) : 191 - 197
  • [23] Influence of CCND1 G870A polymorphism on the risk of HBV-related HCC and cyclin D1 splicing variant expression in Chinese population
    Zeng, Zhenzhen
    Tu, Jing
    Cheng, Jin
    Yao, Mingjie
    Wu, Yali
    Huang, Xiangbo
    Xie, Xiaomeng
    Zhang, Xiaolei
    Lu, Fengmin
    Chen, Xiangmei
    TUMOR BIOLOGY, 2015, 36 (09) : 6891 - 6900
  • [24] Potential Role of CCND1 G870A Genotype as a Predictor for Urothelial Carcinoma Susceptibility and Muscle-Invasiveness in Taiwan
    Lin, Hui-Hui
    Ke, Hung-Lung
    Hsiao, Kuang-Hung
    Tsai, Chia-Wen
    Wu, Wen-Jeng
    Bau, Da-Tian
    Chang, Lin-Li
    CHINESE JOURNAL OF PHYSIOLOGY, 2011, 54 (03): : 196 - 202
  • [25] Critical appraisal and trial sequential meta-analysis for the association of CCND1 G870A gene polymorphism with the risk for colorectal cancer in Asian population
    Mathkor, Darin M.
    Madkhali, Nora
    Mandal, Raju K.
    Dailah, Hamad G.
    Areeshi, Mohammed Y.
    Haque, Shafiul
    MINERVA BIOTECHNOLOGY AND BIOMOLECULAR RESEARCH, 2024, 36 (02): : 34 - 40
  • [26] Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis
    Zhao, Y.
    He, H. R.
    Wang, M. Y.
    Ren, X. D.
    Zhang, L.
    Dong, Y. L.
    Lu, J.
    GENETICS AND MOLECULAR RESEARCH, 2015, 14 (02): : 5171 - 5180
  • [27] CCND1 G870A polymorphism interaction with cigarette smoking increases lung cancer risk: meta-analyses based on 5008 cases and 5214 controls
    Yu-Zhong Duan
    Liang Zhang
    Chang-Chih Liu
    Bo Zhu
    Wen-Lei Zhuo
    Zheng-Tang Chen
    Molecular Biology Reports, 2013, 40 : 4625 - 4635
  • [28] Association between reduced folate carrier G80A polymorphism and methotrexate toxicity in childhood acute lymphoblastic leukemia: a meta-analysis
    He, Hai-Rong
    Liu, Ping
    He, Gong-Hao
    Dong, Wei-Hua
    Wang, Mao-Yi
    Dong, Ya-Lin
    Lu, Jun
    LEUKEMIA & LYMPHOMA, 2014, 55 (12) : 2793 - 2800
  • [29] Polymorphisms of the SLCO1B1 Gene Predict Methotrexate-Related Toxicity in Childhood Acute Lymphoblastic Leukemia
    Lopez-Lopez, Elixabet
    Martin-Guerrero, Idoia
    Ballesteros, Javier
    Angeles Pinan, M.
    Garcia-Miguel, Purificacion
    Navajas, Aurora
    Garcia-Orad, Africa
    PEDIATRIC BLOOD & CANCER, 2011, 57 (04) : 612 - 619
  • [30] Cyclin D1 G870A polymorphism and the risk of hepatocellular carcinoma in a Chinese population
    Hu, Zhangyong
    Zhou, Zhipeng
    Xiong, Guolian
    Wang, Yali
    Lai, Yi
    Deng, Lan
    Yang, Jinliang
    TUMOR BIOLOGY, 2014, 35 (06) : 5607 - 5612
12345