Gene therapy for the treatment of heart failure: promise postponed

被引:102
作者
Hulot, Jean-Sebastien [1 ,2 ]
Ishikawa, Kiyotake [1 ]
Hajjar, Roger J. [1 ]
机构
[1] Icahn Sch Med Mt Sinai, One Gustave L Levy Pl,Box 1030, New York, NY 10029 USA
[2] Univ Paris 06, Pitie Salpetriere Hosp, AP HP, Sorbonne Univ,Inst Cardiometab & Nutr ICAN, F-75013 Paris, France
基金
美国国家卫生研究院;
关键词
Gene therapy; Heart failure; Adeno-associated vectors; Sarcoplasmic reticulum calcium ATPase; Excitation-contraction coupling; IMPROVES CARDIAC-FUNCTION; MYOCARDIAL-INFARCTION; EXPRESSION; MODEL; OVEREXPRESSION; SERCA2A; SUPPRESSION; ADENOVIRUS; CELLS; TRIAL;
D O I
10.1093/eurheartj/ehw019
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Gene therapy has emerged as a powerful tool in targeting the molecular mechanisms implicated in heart failure. Refinements in vector technology, including the development of recombinant adeno-associated vectors, have allowed for safe, long-term, and efficient gene transfer to the myocardium. These advancements, coupled with evolving delivery techniques, have placed gene therapy as a viable therapeutic option for patients with heart failure. However, after much promise in early-phase clinical trials, the more recent larger clinical trials have shown disappointing results, thus forcing the field to re-evaluate current vectors, delivery systems, targets, and endpoints. We provide here an updated review of current cardiac gene therapy programmes that have been or are being translated into clinical trials.
引用
收藏
页码:1651 / 1658
页数:8
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