N-dimethylphosphoryl-protected glucosamine trichloroacetimidate as an effective glycosylation donor

被引：21

作者：

Yang, You

Yu, Biao

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 26期

基金：

中国国家自然科学基金;

关键词：

dimethylphosphoryl; protecting group; glucosamine; trichloroacetimidate; glycosylation;

D O I：

10.1016/j.tetlet.2007.04.150

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Glycosylation of a variety of alcohols with 3,4,6-tri-O-acetyl-2-N-dimethylphosphoryl-2-deoxy-alpha-D-glucopyranosyl trichloroacetimidate as a glycosyl donor provided the corresponding coupled products in high yields and good beta-selectivity. N-Dimethylphosphoryl-protection stayed stable under acidic and basic conditions for further elaboration of the glucosaminecontaining oligosaccharides. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4557 / 4560

页数：4

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