Viral respiratory tract infections and asthma: The course ahead

被引：69

作者：

Rosenthal, Louis A. ^{[1
,2
]}

Avila, Pedro C. ^{[3
]}

Heymann, Peter W. ^{[4
]}

Martin, Richard J. ^{[5
]}

Miller, E. Kathryn ^{[6
]}

Papadopoulos, Nikolaos G. ^{[8
]}

Peebles, R. Stokes, Jr. ^{[7
]}

Gern, James E. ^{[1
,2
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI 53792 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI 53792 USA

[3] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Univ Virginia Hlth Syst, Dept Pediat, Charlottesville, VA USA

[5] Natl Jewish Hlth, Dept Med, Denver, CO USA

[6] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[7] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA

[8] Univ Athens, Dept Allergy, Pediat Clin 2, GR-10679 Athens, Greece

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2010年 / 125卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Viral respiratory tract infections; asthma; wheezing; asthma onset; asthma exacerbations; respiratory tract viruses; rhinovirus; respiratory syncytial virus; allergy; SYNCYTIAL VIRUS-INFECTION; HIGH-RISK CHILDREN; HUMAN RHINOVIRUS; CHILDHOOD ASTHMA; AIRWAY INFLAMMATION; INTERMITTENT ASTHMA; INFANCY; ILLNESSES; EXACERBATIONS; BRONCHIOLITIS;

D O I：

10.1016/j.jaci.2010.04.002

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Inquiries into the relationships between viral respiratory tract illnesses and the inception and exacerbation of asthma are being facilitated by recent advances in research approaches and technology. In this article we identify important knowledge gaps and future research questions, and we discuss how new investigational tools, including improved respiratory tract virus detection techniques, will permit current and future researchers to define these relationships and the host, virus, developmental, and environmental mechanisms that regulate them. A better understanding of these processes should facilitate the development of improved strategies for the prevention and treatment of virus-induced wheezing illnesses and asthma exacerbations and, possibly, the ultimate goal of discovering effective approaches for the primary prevention of asthma. (J Allergy Clin Immunol 2010;125:1212-7.)

引用

页码：1212 / 1217

页数：6

共 36 条

[1] Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation [J].

Bartlett, Nathan W. ;

Walton, Ross P. ;

Edwards, Michael R. ;

Aniscenko, Juliya ;

Caramori, Gaetano ;

Zhu, Jie ;

Glanville, Nicholas ;

Choy, Katherine J. ;

Jourdan, Patrick ;

Burnet, Jerome ;

Tuthill, Tobias J. ;

Pedrick, Michael S. ;

Hurle, Michael J. ;

Plumpton, Chris ;

Sharp, Nigel A. ;

Bussell, James N. ;

Swallow, Dallas M. ;

Schwarze, Jurgen ;

Guy, Bruno ;

WAlmond, Jeffrey ;

Jeffery, Peter K. ;

Lloyd, Clare M. ;

Papi, Alberto ;

Killington, Richard A. ;

Rowlands, David J. ;

Blair, Edward D. ;

Clarke, Neil J. ;

Johnston, Sebastian L. .

NATURE MEDICINE, 2008, 14 (02) :199-204

[2] Montelukast reduces asthma exacerbations in 2-to 5-year-old children with intermittent asthma [J].

Bisgaard, H ;

Zielen, S ;

Garcia-Garcia, ML ;

Johnston, SL ;

Gilles, L ;

Menten, J ;

Tozzi, CA ;

Polos, P .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (04) :315-322

[3] Comprehensive aligned sequence construction for automated design of effective probes (CASCADE-P) using 16S rDNA [J].

DeSantis, TZ ;

Dubosarskiy, I ;

Murray, SR ;

Andersen, GL .

BIOINFORMATICS, 2003, 19 (12) :1461-1468

[4] Preemptive Use of High-Dose Fluticasone for Virus-Induced Wheezing in Young Children. [J].

Ducharme, Francine M. ;

Lemire, Chantal ;

Noya, Francisco J. D. ;

Davis, G. Michael ;

Alos, Nathalie ;

Leblond, Helene ;

Savdie, Cheryl ;

Collet, Jean-Paul ;

Khomenko, Lyudmyla ;

Rivard, Georges ;

Platt, Robert W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (04) :339-353

[5] The acetaminophen and asthma hypothesis 10 years on: A case to answer [J].

Farquhar, Hamish ;

Crane, Julian ;

Mitchell, Edwin A. ;

Eyers, Sally ;

Beasley, Richard .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (04) :649-651

[6] Understanding the mechanisms of viral induced asthma: New therapeutic directions [J].

Hansbro, Nicole G. ;

Horvat, Jay C. ;

Wark, Peter A. ;

Hansbro, Philip M. .

PHARMACOLOGY & THERAPEUTICS, 2008, 117 (03) :313-353

[7] Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing [J].

Heymann, PW ;

Carper, HT ;

Murphy, DD ;

Platts-Mills, TAE ;

Patrie, J ;

McLaughlin, AP ;

Erwin, EA ;

Shaker, MS ;

Hellems, M ;

Peerzada, J ;

Hayden, FG ;

Hatley, TK ;

Chamberlain, R .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 114 (02) :239-247

[8] Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children [J].

Jackson, Daniel J. ;

Gangnon, Ronald E. ;

Evans, Michael D. ;

Roberg, Kathy A. ;

Anderson, Elizabeth L. ;

Pappas, Tressa E. ;

Printz, Magnolia C. ;

Lee, Wai-Ming ;

Shult, Peter A. ;

Reisdorf, Erik ;

Carlson-Dakes, Kirsten T. ;

Salazar, Lisa P. ;

DaSilva, Douglas F. ;

Tisler, Christopher J. ;

Gern, James E. ;

Lemanske, Robert F., Jr. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 178 (07) :667-672

[9] Chronic rhinoviral infection in lung transplant recipients [J].

Kaiser, Laurent ;

Aubert, John-David ;

Pache, Jean-Claude ;

Deffernez, Christelle ;

Rochat, Thierry ;

Garbino, Jorge ;

Wunderli, Werner ;

Meylan, Pascal ;

Yerly, Sabine ;

Perrin, Luc ;

Letovanec, Igor ;

Nicod, Laurent ;

Tapparel, Caroline ;

Soccal, Paola M. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 174 (12) :1392-1399

[10] Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity [J].

Kistler, Amy ;

Avila, Pedro C. ;

Rouskin, Silvi ;

Wang, David ;

Ward, Theresa ;

Yagi, Shigeo ;

Schnurr, David ;

Ganem, Don ;

DeRisi, Joseph L. ;

Boushey, Homer A. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 196 (06) :817-825

← 1 2 3 4 →