Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoide

被引：9

作者：

Elshamy, Abdelsamed, I ^{[1
]}

Mohamed, Tarik A. ^{[2
]}

Elkady, Eman M. ^{[3
]}

Saleh, Ibrahim A. ^{[2
]}

El-Beih, Ahmed A. ^{[4
]}

Alhammady, Montaser A. ^{[3
]}

Ohta, Shinji ^{[5
]}

Umeyama, Akemi ^{[6
]}

Pare, Paul W. ^{[7
]}

Hegazy, Mohamed-Elamir E. ^{[2
,8
]}

机构：

[1] Natl Res Ctr, Dept Nat Cpds Chem, 33 El Bohouth St, Giza 12622, Egypt

[2] Natl Res Ctr, Chem Med Plants Dept, 33 El Bohouth St, Giza 12622, Egypt

[3] Natl Inst Oceanog & Fisheries, NIOF, Cairo 11516, Egypt

[4] Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12622, Egypt

[5] Hiroshima Univ, Grad Sch Integrated Sci Life, 1-7-1 Kagamiyama, Higashihiroshima 7398521, Japan

[6] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro Cho, Tokushima 7708514, Japan

[7] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

[8] Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, Dept Pharmaceut Biol, Staudinger Weg 5, D-55128 Mainz, Germany

来源：

ANTIBIOTICS-BASEL | 2021年 / 10卷 / 10期

关键词：

Paralemnalia thyrsoide; sesquiterpenes; paralemnolins; antimicrobial; NARDOSINANE-TYPE SESQUITERPENOIDS;

D O I：

10.3390/antibiotics10101158

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The organic extracts of the Red Sea soft coral Paralemnalia thyrsoides has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (1, 2). In addition to these newly characterized compounds, ten known metabolites (3-12) were isolated. Previously reported compounds were elucidated by literature comparison of spectroscopic data (1D and 2D NMR as well as MS data). In vitro antimicrobial activity was investigated for compounds (1-12) against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger. Compound 5 showed antimicrobial activity against all assayed microorganisms.

引用

页数：8

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