Chemical composition analysis of soybean oligosaccharides and its effect on ATPase activities in hyperlipidemic rats

A water-soluble oligosaccharide was isolated from the water extract of soybean, which is widely grown worldwide due to its nutritional benefits of a full range of amino acids and a high protein content. In this study, we analysed chemical composition of soybean oligosaccharides (SBOS) using high performance liquid chromatography (HPLC) The results obtained were compared with the following sugar standards: mannose, galactose, xylose. arabinose, fucose and glucose Results showed that SBOS was composed of galactose (65.3%). mannose (15 6%), fructose (7 8%) and glucose (8.7%) The pharmacological action of SBOS has been studied in hyperlipidemic rats fed high-fat diet In hyperlipidemic rats, feeding with SBOS ( 150 and 300 mg/kg b w) exerted a pharmacological effect as assessed by reversal of plasma levels of lactic acid, nitric oxide (NO). vascular endothelial growth factor (VEGF) levels. and heart Na+-K+-ATPase. Ca2+-ATPase and Mg2+-ATPase activities These results indicated that SBOS may have beneficial effects on the therapy of some heart diseases, such as coronary artery diseases. (C) 2009 Elsevier B V All rights reserved