Ghrelin levels are reduced in prepubertal epileptic children under treatment with carbamazepine or valproic acid

被引：21

作者：

Prodam, Flavia ^{[1
]}

Bellone, Simonetta ^{[1
]}

Casara, Gianluca ^{[2
]}

De Rienzo, Francesca ^{[1
]}

Grassino, Erica C. ^{[1
]}

Bonsignori, Ilaria ^{[1
]}

Demarchi, Irene ^{[1
]}

Rapa, Anna ^{[1
]}

Radetti, Giorgio ^{[2
]}

Bona, Gianni ^{[1
]}

机构：

[1] Univ Piemonte Orientale, Div Pediat, Dept Med Sci, I-28100 Novara, Italy

[2] Reg Hosp Bolzano, Dept Pediat, Bolzano, Italy

来源：

EPILEPSIA | 2010年 / 51卷 / 02期

关键词：

Ghrelin; Seizures; Human; Children; BMI; SERUM GHRELIN; SEIZURES;

D O I：

10.1111/j.1528-1167.2009.02307.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A relationship between ghrelin and epilepsy has been already shown in humans, although the results are controversial. Ghrelin levels are reduced in obesity. Epileptic patients progressively develop a therapy-linked weight gain; however, the mechanisms for this have not been fully explained. The aim of our study is to evaluate if ghrelin secretion is modulated by treatment with carbamazepine or valproic acid in young prepubertal epileptic children. Ghrelin levels were reduced in normal-weight young epileptic prepubertal children under treatment with carbamazepine (p < 0.0001) or valproic acid (p < 0.006) compared to healthy age- and weight-matched subjects. Ghrelin was also lower in children under carbamazepine when compared to those under valproic acid (p < 0.01). A derangement in ghrelin secretion in epilepsy during specific pharmacologic therapies and independent of weight gain could be hypothesized.

引用

页码：312 / 315

页数：4

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