The Bidirectional Relationship Between Cancer Epigenetics and Metabolism

被引：29

作者：

Izzo, Luke T.

Affronti, Hayley C.

Wellen, Kathryn E. ^{[1
]}

机构：

[1] Univ Penn, Dept Canc Biol, Philadelphia, PA 19104 USA

来源：

ANNUAL REVIEW OF CANCER BIOLOGY, VOL 5, 2021 | 2021年 / 5卷

基金：

美国国家卫生研究院;

关键词：

cell metabolism; epigenetics; chromatin modification; cancer; ATP-CITRATE LYASE; HISTONE DEACETYLASE SIRT6; ACETYL-COA; DIETARY-FOLATE; PROTEIN-KINASE; DNA METHYLATION; INHIBITION; GROWTH; DEFICIENCY; ACETATE;

D O I：

10.1146/annurev-cancerbio-070820-035832

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence the availability of metabolites that are substrates or inhibitors of epigenetic enzymes. Reciprocally, altered expression or activity of chromatin-modifying enzymes can exert direct and indirect effects on cellular metabolism. In this article, we discuss the bidirectional relationship between epigenetics and metabolism in cancer. First, we focus on epigenetic control of metabolism, highlighting evidence that alterations in histone modifications, chromatin remodeling, or the enhancer landscape can drive metabolic features that support growth and proliferation. We then discuss metabolic regulation of chromatin-modifying enzymes and roles in tumor growth and progression. Throughout, we highlight proposed therapeutic and dietary interventions that leverage metabolic-epigenetic cross talk and have the potential to improve cancer therapy.

引用

页码：235 / 257

页数：23

共 149 条

[1] Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model [J].

Affronti, Hayley C. ;

Long, Mark D. ;

Rosario, Spencer R. ;

Gillard, Bryan M. ;

Karasik, Ellen ;

Boerlin, Christoph S. ;

Pellerite, Anthony J. ;

Foster, Barbara A. ;

Attwood, Kristopher ;

Pili, Roberto ;

Wilton, John H. ;

Campbell, Moray J. ;

Smiraglia, Dominic J. .

ONCOTARGET, 2017, 8 (61) :103758-103774

[2] Ascorbate regulates haematopoietic stem cell function and leukaemogenesis [J].

Agathocleous, Michalis ;

Meacham, Corbin E. ;

Burgess, Rebecca J. ;

Piskounova, Elena ;

Zhao, Zhiyu ;

Crane, Genevieve M. ;

Cowin, Brianna L. ;

Bruner, Emily ;

Murphy, Malea M. ;

Chen, Weina ;

Spangrude, Gerald J. ;

Hu, Zeping ;

DeBerardinis, Ralph J. ;

Morrison, Sean J. .

NATURE, 2017, 549 (7673) :476-+

[3] KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer [J].

Alam, Hunain ;

Tang, Ming ;

Maitituoheti, Mayinuer ;

Dhar, Shilpa S. ;

Kumar, Manish ;

Han, Chae Young ;

Ambati, Chandrashekar R. ;

Amin, Samir B. ;

Gu, Bingnan ;

Chen, Tsai-Yu ;

Lin, Yu-Hsi ;

Chen, Jichao ;

Muller, Florian L. ;

Putluri, Nagireddy ;

Flores, Elsa R. ;

DeMayo, Francesco J. ;

Baseler, Laura ;

Rai, Kunal ;

Lee, Min Gyu .

CANCER CELL, 2020, 37 (04) :599-+

[4] α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis [J].

Atlante, Sandra ;

Visintin, Alessia ;

Marini, Elisabetta ;

Savoia, Matteo ;

Dianzani, Chiara ;

Giorgis, Marta ;

Surun, Duran ;

Maione, Federica ;

Schnutgen, Frank ;

Farsetti, Antonella ;

Zeiher, Andreas M. ;

Bertinaria, Massimo ;

Giraudo, Enrico ;

Spallotta, Francesco ;

Cencioni, Chiara ;

Gaetano, Carlo .

CELL DEATH & DISEASE, 2018, 9

[5] Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer [J].

Attar, Narsis ;

Kurdistani, Siavash K. .

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2017, 7 (03)

[6] Methylthioadenosine [J].

Avila, MA ;

García-Trevijano, ER ;

Lu, SC ;

Corrales, FJ ;

Mato, JM .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2004, 36 (11) :2125-2130

[7] The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes [J].

Berwick, DC ;

Hers, I ;

Heesom, KJ ;

Moule, SK ;

Tavaré, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (37) :33895-33900

[8] Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells [J].

Bialopiotrowicz, Emilia ;

Noyszewska-Kania, Monika ;

Kachamakova-Trojanowska, Neli ;

Loboda, Agnieszka ;

Cybulska, Magdalena ;

Grochowska, Aleksandra ;

Kopczynski, Michal ;

Mikula, Michal ;

Prochorec-Sobieszek, Monika ;

Firczuk, Malgorzata ;

Graczyk-Jarzynka, Agnieszka ;

Zagozdzon, Radoslaw ;

Zabek, Adam ;

Mlynarz, Piotr ;

Dulak, Jozef ;

Gorniak, Patryk ;

Szydlowski, Maciej ;

Pyziak, Karolina ;

Martyka, Justyna ;

Sroka-Porada, Agnieszka ;

Jablonska, Ewa ;

Polak, Anna ;

Kowalczyk, Piotr ;

Szumera-Cieckiewicz, Anna ;

Chapuy, Bjoern ;

Rzymski, Tomasz ;

Brzozka, Krzysztof ;

Juszczynski, Przemyslaw .

CANCERS, 2020, 12 (03)

[9] Cancer SLC43A2 alters T cell methionine metabolism and histone methylation [J].

Bian, Yingjie ;

Li, Wei ;

Kremer, Daniel M. ;

Sajjakulnukit, Peter ;

Li, Shasha ;

Crespo, Joel ;

Nwosu, Zeribe C. ;

Zhang, Li ;

Czerwonka, Arkadiusz ;

Pawlowska, Anna ;

Xia, Houjun ;

Li, Jing ;

Liao, Peng ;

Yu, Jiali ;

Vatan, Linda ;

Szeliga, Wojciech ;

Wei, Shuang ;

Grove, Sara ;

Liu, J. Rebecca ;

McLean, Karen ;

Cieslik, Marcin ;

Chinnaiyan, Arul M. ;

Zgodzinski, Witold ;

Wallner, Grzegorz ;

Wertel, Iwona ;

Okla, Karolina ;

Kryczek, Ilona ;

Lyssiotis, Costas A. ;

Zou, Weiping .

NATURE, 2020, 585 (7824) :277-+

[10] Dietary Folate Deficiency Blocks Prostate Cancer Progression in the TRAMP Model [J].

Bistulfi, Gaia ;

Foster, Barbara A. ;

Karasik, Ellen ;

Gillard, Bryan ;

Miecznikowski, Jeff ;

Dhiman, Vineet K. ;

Smiraglia, Dominic J. .

CANCER PREVENTION RESEARCH, 2011, 4 (11) :1825-1834

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