Gatekeepers of intestinal inflammation

被引：14

作者：

Arnett, Heather A. ^{[2
]}

Viney, Joanne L. ^{[1
]}

机构：

[1] Amgen Inc, Inflammat Res, Thousand Oaks, CA 91320 USA

[2] Amgen Inc, Inflammat Res, Seattle, WA 98119 USA

来源：

INFLAMMATION RESEARCH | 2010年 / 59卷 / 01期

关键词：

Costimulatory receptors; Defensins; IBD; Immunomodulators; Cytokines; REGULATORY T-CELLS; RECOMBINANT HUMAN INTERLEUKIN-10; MAJOR HISTOCOMPATIBILITY COMPLEX; SPLICE-SITE MUTATION; LYMPHOCYTE-ASSOCIATED ANTIGEN-4; GENOME-WIDE ASSOCIATION; SULFONIC-ACID COLITIS; ACTIVE CROHNS-DISEASE; GROWTH-FACTOR-BETA; BOWEL-DISEASE;

D O I：

10.1007/s00011-009-0091-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The intestine is subjected to a barrage of insults from food, bacterial flora, and pathogens. Despite this constant antigenic challenge, the mucosal tissues lining the intestinal tract remain largely under control. The mechanisms regulating the homeostatic balance in the gut have been investigated for many years by many groups, but the precise nature of the regulatory control remains elusive. In this review, we provide an overview of pathways proposed to be involved in dampening the inflammatory response and maintaining the homeostatic balance in the intestine, and how these pathways may be disrupted in ulcerative colitis and Crohn's disease.

引用

页码：1 / 14

页数：14

共 179 条

[101] Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis [J].

Melgar, S ;

Yeung, MMW ;

Bas, A ;

Forsberg, G ;

Suhr, O ;

Öberg, Å ;

Hammarström, S ;

Danielsson, Å ;

Hammarström, ML .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2003, 134 (01) :127-137

[102] IDO expression by dendritic cells: Tolerance and tryptophan catabolism [J].

Mellor, AL ;

Munn, DH .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (10) :762-774

[103] Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses [J].

Mellor, AL ;

Keskin, DB ;

Johnson, T ;

Chandler, P ;

Munn, DH .

JOURNAL OF IMMUNOLOGY, 2002, 168 (08) :3771-3776

[104] Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis [J].

Meresse, B. ;

Ripoche, J. ;

Heyman, M. ;

Cerf-Bensussan, N. .

MUCOSAL IMMUNOLOGY, 2009, 2 (01) :8-23

[105] Isolated cardiac sarcoidosis associated with the expression of a splice variant coding for a truncated BTNL2 protein [J].

Meyer, Thomas ;

Lauschke, Joerg ;

Ruppert, Volker ;

Richter, Anette ;

Pankuweit, Sabine ;

Maisch, Bernhard .

CARDIOLOGY, 2008, 109 (02) :117-121

[106] Effect of a Probiotic Preparation (VSL# 3) on Induction and Maintenance of Remission in Children With Ulcerative Colitis [J].

Miele, Erasmo ;

Pascarella, Filomena ;

Giannetti, Eleonora ;

Quaglietta, Lucia ;

Baldassano, Robert N. ;

Staiano, Annamaria .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2009, 104 (02) :437-443

[107] Butyrophilin-like 2 gene is associated with ulcerative colitis in the Japanese under strong linkage disequilibrium with HLA-DRB1*1502 [J].

Mochida, A. ;

Kinouchi, Y. ;

Negoro, K. ;

Takahashi, S. ;

Takagi, S. ;

Nomura, E. ;

Kakuta, Y. ;

Tosa, M. ;

Shimosegawa, T. .

TISSUE ANTIGENS, 2007, 70 (02) :128-135

[108] Allelic variation in BTNL2 and susceptibility to tuberculosis in a South African population [J].

Moeller, Marlo ;

Kwiatkowski, Ruta ;

Nebel, Almut ;

van Helden, Paul D. ;

Hoal, Eileen G. ;

Schreiber, Stefan .

MICROBES AND INFECTION, 2007, 9 (04) :522-528

[109] Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase [J].

Molano, Alberto ;

Illarionov, Petr A. ;

Besra, Gurdyal S. ;

Putterman, Chaim ;

Porcelli, Steven A. .

IMMUNOLOGY LETTERS, 2008, 117 (01) :81-90

[110] CD4+ T-CELLS THAT EXPRESS HIGH-LEVELS OF CD45RB INDUCE WASTING DISEASE WHEN TRANSFERRED INTO CONGENIC SEVERE COMBINED IMMUNODEFICIENT MICE - DISEASE DEVELOPMENT IS PREVENTED BY COTRANSFER OF PURIFIED CD4+ T-CELLS [J].

MORRISSEY, PJ ;

CHARRIER, K ;

BRADDY, S ;

LIGGITT, D ;

WATSON, JD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (01) :237-244

← 6 7 8 9 10 11 12 13 14 15 →