Gatekeepers of intestinal inflammation

被引：14

作者：

Arnett, Heather A. ^{[2
]}

Viney, Joanne L. ^{[1
]}

机构：

[1] Amgen Inc, Inflammat Res, Thousand Oaks, CA 91320 USA

[2] Amgen Inc, Inflammat Res, Seattle, WA 98119 USA

来源：

INFLAMMATION RESEARCH | 2010年 / 59卷 / 01期

关键词：

Costimulatory receptors; Defensins; IBD; Immunomodulators; Cytokines; REGULATORY T-CELLS; RECOMBINANT HUMAN INTERLEUKIN-10; MAJOR HISTOCOMPATIBILITY COMPLEX; SPLICE-SITE MUTATION; LYMPHOCYTE-ASSOCIATED ANTIGEN-4; GENOME-WIDE ASSOCIATION; SULFONIC-ACID COLITIS; ACTIVE CROHNS-DISEASE; GROWTH-FACTOR-BETA; BOWEL-DISEASE;

D O I：

10.1007/s00011-009-0091-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The intestine is subjected to a barrage of insults from food, bacterial flora, and pathogens. Despite this constant antigenic challenge, the mucosal tissues lining the intestinal tract remain largely under control. The mechanisms regulating the homeostatic balance in the gut have been investigated for many years by many groups, but the precise nature of the regulatory control remains elusive. In this review, we provide an overview of pathways proposed to be involved in dampening the inflammatory response and maintaining the homeostatic balance in the intestine, and how these pathways may be disrupted in ulcerative colitis and Crohn's disease.

引用

页码：1 / 14

页数：14

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