Multi-country study on the prevalence and clinical features of peripheral arterial disease in Asian type 2 diabetes patients at high risk of atherosclerosis

被引:55
作者
Rhee, Sang Youl
Guan, Heng
Liu, Zhi Min
Cheng, Stephen Wing-Keung
Waspadji, Sarwono
Palmes, Patricio
Tai, Tong Yuan
Suwanwalaikorn, Sompongse
Kim, Young Seol
机构
[1] Kyung Hee Univ, Dept Endocrinol & Metab, Sch Med, Coll Med, Seoul, South Korea
[2] Peking Union Med Coll Hosp, Dept Vasc Surg, Beijing, Peoples R China
[3] Shanghai Changzheng Hosp, Dept Endocrinol, Shanghai, Peoples R China
[4] Univ Hong Kong, Med Ctr, Queen Mary Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China
[5] Univ Indonesia, Dr Cipto Mangunkusumo Hosp, Dept Endocrinol & Metab, Sch Med, Jakarta, Indonesia
[6] W Visayas State Univ Hosp, Dept Endocrinol & Metab, Iloilo, Philippines
[7] Natl Taiwan Univ Hosp, Dept Endocrinol & Metab, Taipei, Taiwan
[8] King Chulalongkorn Mem Hosp, Dept Endocrinol, Bangkok, Thailand
关键词
diabetes mellitus; diabetes complications; risk factors; peripheral vascular diseases; epidemiology; Asia;
D O I
10.1016/j.diabres.2006.07.029
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: PAD-SEARCH was the first international study to investigate the,prevalence of peripheral arterial disease (PAD) in Asian type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD. S ubjects and methods: In total 6625 type 2 diabetic patients aged 50 and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in Korea, China, Taiwan, Hong Kong, Indonesia, Thailand and the Philippines. Results: Mean patient age was 63.7 +/- 8.2 years and mean duration of diabetes was 10.3 +/- 8.0 years. One thousand one hundred and seventy-two (17.7%) subjects were diagnosed as PAD by ABI (<= 0.9). PAD subjects had a significantly longer duration of diabetes, hypertension, higher HbA1c, and a significantly lower mean BMI than non-PAD subjects. In terms of lipid profiles, triglyceride was the only significant variable. Notably, mean ABI and baPWV in females were significantly poorer than age matched males in subjects with a normal ABI. However, mean ABI and baPWV in males were significantly poorer than in age matched females in subjects with PAD. Conclusions: These findings suggest that PAD is a common complication in Asian type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for Asian diabetic patients with high risk factors. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:82 / 92
页数:11
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