Perioperative Outcomes of Minimally Invasive Esophagectomy After Neoadjuvant Immunotherapy for Patients With Locally Advanced Esophageal Squamous Cell Carcinoma

被引：25

作者：

Cheng, Jiahan ^{[1
]}

Guo, Minzhang ^{[1
]}

Yang, Yushang ^{[1
]}

Liu, Yilin ^{[2
]}

Hu, Weipeng ^{[1
]}

Shang, Qixin ^{[1
]}

Li, Chuan ^{[1
]}

Xia, Liang ^{[1
]}

Wang, Yun ^{[1
]}

Wang, Wenping ^{[1
]}

Tian, Dong ^{[1
]}

Yuan, Yong ^{[1
]}

Hu, Yang ^{[1
]}

Chen, Longqi ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Thorac Surg, Chengdu, Peoples R China

[2] Sichuan Univ, West China Hosp, Inst Thorac Oncol, Chengdu, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

esophageal squamous cell carcinoma; neoadjuvant combination of chemotherapy and immunotherapy; neoadjuvant chemotherapy plus radiotherapy; perioperative outcomes; safety and efficiency; 8TH EDITION; CANCER; SURGERY; CHEMORADIOTHERAPY; CLASSIFICATION; MULTICENTER; JUNCTION;

D O I：

10.3389/fimmu.2022.848881

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BackgroundImmunotherapy has become a pillar of advanced solid tumors treatment. Patients are more likely to benefit from neoadjuvant immunotherapy compared with traditional neoadjuvant therapy. However, the safety and efficacy of neoadjuvant immunotherapy for the treatment of locally advanced, surgically resectable Esophageal squamous cell carcinoma (ESCC) remain unknown. MethodESCC patients who received neoadjuvant treatment following minimally invasive esophagogastrostomy were enrolled from June 2020 to September 2021. The characteristics of neoadjuvant treatment and surgery were investigated to determine the safety and efficacy of the neoadjuvant combination of chemotherapy and immunotherapy (NCI). ResultsA total of 149 patients were included in the study. Patient ratio was 40:109 between NCI and neoadjuvant chemotherapy plus radiotherapy (NCR) groups. No significant difference was found in terms of pathological characteristics, including ypN stage, ypTNM stage, differentiation, lymphovascular invasion, perineural invasion, pathological complete regression and tumor regression score, and these parameters were not correlated with NCI or NCR (all p>0.05). Regarding to the operation, the NCI group had less blood loss (49.25 +/- 13.47 vs. 57.02 +/- 47.26, p<0.001), and shorter operation time (247.75 +/- 28.28 vs. 285.83 +/- 52.43, p<0.001) than the NCR group. Additionally, the NCI group demonstrated a lower rate of overall perioperative complications (p=0.003) and grade >2 perioperative complications (p=0.042) than the NCR group. ConclusionOverall, the findings reported here indicate NCI could result in better outcome and less complications to locally advanced ESCC patients compared with NCR therapy. As a novel therapeutic option, the efficacy and safety of NCI appears to be feasible and safe, while long-term survival data is still needed.

引用

页数：10

共 34 条

[1] The Prevalence of Overall and Initial Lymph Node Metastases in Clinical T1N0 Thoracic Esophageal Cancer From the Results of JCOG0502, a Prospective Multicenter Study [J].

Akutsu, Yasunori ;

Kato, Ken ;

Igaki, Hiroyasu ;

Ito, Yoshinori ;

Nozaki, Isao ;

Daiko, Hiroyuki ;

Yano, Masahiko ;

Udagawa, Harushi ;

Nakagawa, Satoru ;

Takagi, Masakazu ;

Mizusawa, Junki ;

Kitagawa, Yuko .

ANNALS OF SURGERY, 2016, 264 (06) :1009-1015

[2] Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma [J].

Amaria, Rodabe N. ;

Reddy, Sangeetha M. ;

Tawbi, Hussein A. ;

Davies, Michael A. ;

Ross, Merrick, I ;

Glitza, Isabella C. ;

Cormier, Janice N. ;

Lewis, Carol ;

Hwu, Wen-Jen ;

Hanna, Ehab ;

Diab, Adi ;

Wong, Michael K. ;

Royal, Richard ;

Gross, Neil ;

Weber, Randal ;

Lai, Stephen Y. ;

Ehlers, Richard ;

Blando, Jorge ;

Milton, Denai R. ;

Woodman, Scott ;

Kageyama, Robin ;

Wells, Daniel K. ;

Hwu, Patrick ;

Patel, Sapna P. ;

Lucci, Anthony ;

Hessel, Amy ;

Lee, Jeffrey E. ;

Gershenwald, Jeffrey ;

Simpson, Lauren ;

Burton, Elizabeth M. ;

Posada, Liberty ;

Haydu, Lauren ;

Wang, Linghua ;

Zhang, Shaojun ;

Lazar, Alexanderj ;

Hudgens, Courtney W. ;

Gopalakrishnan, Vancheswaran ;

Reuben, Alexandre ;

Andrews, Miles C. ;

Spencer, Christine N. ;

Prieto, Victor ;

Sharma, Padmanee ;

Allison, James ;

Tetzlaff, Michael T. ;

Wargo, Jennifer A. .

NATURE MEDICINE, 2018, 24 (11) :1649-+

[3] Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial [J].

Biere, Surya S. A. Y. ;

Henegouwen, Mark I. van Berge ;

Maas, Kirsten W. ;

Bonavina, Luigi ;

Rosman, Camiel ;

Roig Garcia, Josep ;

Gisbertz, Suzanne S. ;

Klinkenbijl, Jean H. G. ;

Hollmann, Markus W. ;

de lange, Elly S. M. ;

Bonjer, H. Jaap ;

van der Peet, Donald L. ;

Cuesta, Miguel A. .

LANCET, 2012, 379 (9829) :1887-1892

[4]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[5] Is concurrent radiation therapy required in patients receiving preoperative chemotherapy for adenocarcinoma of the oesophagus? A randomised phase II trial [J].

Burmeister, Bryan H. ;

Thomas, Janine M. ;

Burmeister, Elizabeth A. ;

Walpole, Euan T. ;

Harvey, Jennifer A. ;

Thomson, Damien B. ;

Barbour, Andrew P. ;

Gotley, David C. ;

Smithers, B. Mark .

EUROPEAN JOURNAL OF CANCER, 2011, 47 (03) :354-360

[6] Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers [J].

Chalabi, Myriam ;

Fanchi, Lorenzo F. ;

Dijkstra, Krijn K. ;

Van den Berg, Jose G. ;

Aalbers, Arend G. ;

Sikorska, Karolina ;

Lopez-Yurda, Marta ;

Grootscholten, Cecile ;

Beets, Geerard L. ;

Snaebjornsson, Petur ;

Maas, Monique ;

Mertz, Marjolijn ;

Veninga, Vivien ;

Bounova, Gergana ;

Broeks, Annegien ;

Beets-Tan, Regina G. ;

de Wijkerslooth, Thomas R. ;

van Lent, Anja U. ;

Marsman, Hendrik A. ;

Nuijten, Elvira ;

Kok, Niels F. ;

Kuiper, Maria ;

Verbeek, Wieke H. ;

Kok, Marleen ;

Van Leerdam, Monique E. ;

Schumacher, Ton N. ;

Voest, Emile E. ;

Haanen, John B. .

NATURE MEDICINE, 2020, 26 (04) :566-+

[7] Grading dermatologic adverse events of cancer treatments: The Common Terminology Criteria for Adverse Events Version 4.0 [J].

Chen, Alice P. ;

Setser, Ann ;

Anadkat, Milan J. ;

Cotliar, Jonathan ;

Olsen, Elise A. ;

Garden, Benjamin C. ;

Lacouture, Mario E. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 67 (05) :1025-1039

[8] The Clavien-Dindo Classification of Surgical Complications Five-Year Experience [J].

Clavien, Pierre A. ;

Barkun, Jeffrey ;

de Oliveira, Michelle L. ;

Vauthey, Jean Nicolas ;

Dindo, Daniel ;

Schulick, Richard D. ;

de Santibanes, Eduardo ;

Pekolj, Juan ;

Slankamenac, Ksenija ;

Bassi, Claudio ;

Graf, Rolf ;

Vonlanthen, Rene ;

Padbury, Robert ;

Cameron, John L. ;

Makuuchi, Masatoshi .

ANNALS OF SURGERY, 2009, 250 (02) :187-196

[9] Risk Prediction Model of 90-Day Mortality After Esophagectomy for Cancer [J].

D'Journo, Xavier Benoit ;

Boulate, David ;

Fourdrain, Alex ;

Loundou, Anderson ;

Henegouwen, Mark I. van Berge ;

Gisbertz, Suzanne S. ;

O'Neill, J. Robert ;

Hoelscher, Arnulf ;

Piessen, Guillaume ;

van Lanschot, Jan ;

Wijnhoven, Bas ;

Jobe, Blair ;

Davies, Andrew ;

Schneider, Paul M. ;

Pera, Manuel ;

Nilsson, Magnus ;

Nafteux, Philippe ;

Kitagawa, Yuko ;

Morse, Christopher R. ;

Hofstetter, Wayne ;

Molena, Daniela ;

So, Jimmy Bok-Yan ;

Immanuel, Arul ;

Parsons, Simon L. ;

Larsen, Michael Hareskov ;

Dolan, James P. ;

Wood, Stephanie G. ;

Maynard, Nick ;

Smithers, Mark ;

Puig, Sonia ;

Law, Simon ;

Wong, Ian ;

Kennedy, Andrew ;

KangNing, Wang ;

Reynolds, John V. ;

Pramesh, C. S. ;

Ferguson, Mark ;

Darling, Gail ;

Schroder, Wolfgang ;

Bludau, Marc ;

Underwood, Tim ;

van Hillegersberg, Richard ;

Chang, Andrew ;

Cecconello, Ivan ;

Ribeiro, Ulysses, Jr. ;

de Manzoni, Giovanni ;

Rosati, Riccardo ;

Kuppusamy, MadhanKumar ;

Thomas, Pascal Alexandre ;

Low, Donald E. .

JAMA SURGERY, 2021, 156 (09) :836-845

[10] Neoadjuvant PD-1 Blockade in Resectable Lung Cancer [J].

Forde, P. M. ;

Chaft, J. E. ;

Smith, K. N. ;

Anagnostou, V. ;

Cottrell, T. R. ;

Hellmann, M. D. ;

Zahurak, M. ;

Yang, S. C. ;

Jones, D. R. ;

Broderick, S. ;

Battafarano, R. J. ;

Velez, M. J. ;

Rekhtman, N. ;

Olah, Z. ;

Naidoo, J. ;

Marrone, K. A. ;

Verde, F. ;

Guo, H. ;

Zhang, J. ;

Caushi, J. X. ;

Chan, H. Y. ;

Sidhom, J. -W. ;

Scharpf, R. B. ;

White, J. ;

Gabrielson, E. ;

Wang, H. ;

Rosner, G. L. ;

Rusch, V. ;

Wolchok, J. D. ;

Merghoub, T. ;

Taube, J. M. ;

Velculescu, V. E. ;

Topalian, S. L. ;

Brahmer, J. R. ;

Pardoll, D. M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (21) :1976-1986

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